摘要
目的 探讨低水平铅暴露对儿童神经行为的影响。方法 整群随机抽取某市幼儿园 4～ 6岁 2 11名儿童为研究对象 ,采指端末梢血 2 0 μl,原子吸收石墨炉法测定血铅 ,以血铅水平 10 0 μg/L为界 ,分为高血铅组(≥ 10 0 μg/L)和低血铅组 (<10 0 μg/L) ,采用Achenbach儿童行为量表 (CBCL)及自拟调查表进行问卷调查 ,其结果运用t ,χ2 检验 ,简相关及多元逐步回归等方法进行统计分析。结果 高血铅组外向行为得分及行为异常率(13.2 8± 6 .2 6 ,18.2 6 % )显著高于低血铅组 (9.98± 5 .4 6 ,7.2 9% ) (t =4 .0 6 77,χ2 =5 .4 70 ,均P <0 .0 5 ) ,血铅值与外向行为中多动、攻击、违纪因子分显著正相关 (r =0 .316 4 ,0 .2 82 8,0 .1886 ,P <0 .0 5 ) ,血铅值≥ 15 0 μg/L时 ,行为异常率显著增加 (χ2 =13.6 95 ,P <0 .0 5 )。结论 低水平铅暴露对儿童外向行为具有负性影响。
Objective To study the effects of exposure to low level lead on neurobehaviors of preschool children. Methods Blood lead levels were measured in 211 preschool children aged 4-6 years in a kindergarten without known exposure to lead sources; the 211 children were assigned into two groups: low blood lead level group (LL group, <100 μg/L ) and high blood lead level group (HL group, ≥100 μg/L). Their neurobehaviors were assessed with Achenbach child behavior checklist (CBCL) to study the relationship between blood lead and CBCL total behavior scores (TBPs), internalizing and externalizing scores (Ints and Exts). Results The Exts and incidence of abnormal behavior problems in the HL group ( 13.28 ± 6.26 and 18.26% , respectively) were much higher than those in the LL group ( 9.98 ± 5.46 and 7.29% , respectively)(t= 4.0677 , χ 2= 5.470 , P< 0.05 ). The blood lead level was positively correlated significantly with the scores for hyperactivity, attack and disobedience (r= 0.3164 , 0.2828 , 0.1886 , P< 0.05 ). When the blood lead levels of children reached or exceeded 150 μg/L, the incidence of abnormal behavior problems increased significantly. Conclusions Low level lead exposure can have adverse effects on neurobehaviors of preschool children.
出处
《中国当代儿科杂志》
CAS
CSCD
2002年第4期303-304,共2页
Chinese Journal of Contemporary Pediatrics
关键词
低水平铅暴露
神经行为
儿童
Low level lead exposure
Neurobehavior
Child
