摘要
目的探讨游离睾酮指数对诊断多囊卵巢综合征（PCOS）的意义。
方法选择确诊为PCOS的患者58例为实验组，选取同期进行体检的健康妇女58例为对照组。对所有研究对象进行体征评分、测定相关激素指标并计算出游离睾酮指数（FAI）。观察比较两组体征情况及内分泌指标水平等。
结果实验组月经正常率（13.79%）显著低于对照组（96.55%），差异有统计学意义（P〈0.05）；实验组多毛率（74.14%）及痤疮率（70.69%）明显高于对照组，差异均有统计学意义（P〈0.05）。实验组黄体生成素（LH）、游离睾酮（FT）及游离睾酮指数（FAI）水平均显著高于对照组（P〈0.05）；实验组卵泡刺激素（FSH）及总睾酮（TT）水平与对照组比较差异未见统计学意义（P〉0.05）。FAI与多毛、痤疮的符合率显著高于TT及FT（P〈0.05），TT灵敏度较低、特异度较高，而FT及FAI灵敏度较高、特异度较低。TT、FT及FAI对PCOS的诊断符合率分别为30.6%、21.4%、74.3%，FAI的诊断率显著高于TT及FT，差异均有统计学意义（P〈0.05）；TT与FT比较差异未见统计学意义（P〉0.05）。
结论FAI与多毛、痤疮的符合率最高，且FAI诊断PCOS敏感性更高，即FAI更能体现PCOS患者血清睾酮的生物活性水平，是诊断PCOS患者高雄激素血症的敏感指标，在临床上具有较高的应用价值。
ObjectiveTo investigate the significance of free testosterone index in the diagnosis of polycystic ovary syndrome （PCOS）.
MethodsFifty-eight patients with PCOS were selected as the experimental group, and 58 healthy women at the same period were selected as the control group. The signs of all the subjects were scored, the related hormone indexes were measured and the testosterone index （FAI） was calculated. The physical signs and endocrine indexes of the two groups were observed and compared.
ResultsThe normal rate of menstruation in the experimental group （13.79%） was significantly lower than that of the control group （96.55%）, and the difference was significant （P〈0.05）. In the experimental group, the hairy rate （74.14%） and the acne rate （70.69%） was significantly higher than those in the control group, and the differences were significant （P〈0.05）. The luteinizing hormone （LH）, free testosterone （FT） and free testosterone index （FAI） of the experimental group were significantly higher than those in control group （P〈0.05）; the follicle stimulating hormone （FSH） and total testosterone （TT） levels of the experimental group compared with the control group, there was no significant difference （P〉0.05）. The coincidence rate of FAI with hirsute and acne was significantly higher than that of TT and FT （P〈0.05）. TT has low sensitivity and high specificity, while FT and FAI have high sensitivity and low specificity. The diagnostic accordance rate of TT, FT and FAI for PCOS respectively were 30.6%, 21.4%, 74.3%, and the diagnostic rate of FAI was significantly higher than that of TT and FT, the differences were significant （P〈0.05）, and there was no significant difference between TT and FT （P〉0.05）.
Conclusions
FAI has the highest coincidence rate with hirsutism acne, and FAI was the more sensitive for the diagnosis of PCOS. FAI can reflect the biological activity of serum testosterone in patients with PCOS better, and it is a sensitive indicator for PCOS patients with hyperandrogenism. FAI has high clinical value.
作者
董丽娜
Dong Lina(Department of Clinical Laboratory, Puyang Hospital of Traditional Chinese Medicine, Puyang 457003, Chin)
出处
《中国实用医刊》
2018年第6期74-77,共4页
Chinese Journal of Practical Medicine
关键词
多囊卵巢综合征
游离睾酮指数
高雄激素血症
诊断
Polycystic ovary syndrome
Free testosterone index
Hyperandrogenism
Diagnosis
