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沙丁胺醇联合布地奈德对哮喘患者炎性反应及肺功能指标的影响 被引量:1

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摘要 目的探究沙丁胺醇联合布地奈德对哮喘患者炎性反应及肺功能指标的影响。方法选取2016年3月—2017年2月收治的哮喘患者106例,按照随机数表法将其分为两组,各53例。两组均进行常规对症治疗,对照组给予硫酸沙丁胺醇气雾剂治疗,观察组增加布地奈德雾化吸入治疗。比较两组炎性反应[C反应蛋白(CRP)、白介素-13(IL-13)、白介素-8(IL-8)、肿瘤坏死因子α(TNF-α)]、肺功能[用力肺活量(FVC)、1 s用力呼气容积(FEV1)、FEV1/FVC]、治疗效果及不良反应情况。计量资料比较采用t检验,计数资料比较采用χ2检验,P<0.05为差异有统计学意义。结果观察组治疗总有效率(94.34%)高于对照组(77.36%)(P<0.05)。治疗后,观察组CRP、IL-13、IL-8、TNF-α水平低于对照组(均P<0.05);观察组FVC、FEV1、FEV1/FVC水平高于对照组(均P<0.05);两组不良反应比较差异无统计学意义(P>0.05)。结论沙丁胺醇联合布地奈德治疗哮喘效果显著,可有效降低机体炎性反应,促进肺功能恢复。
作者 刘云
出处 《社区医学杂志》 2018年第3期35-36,共2页 Journal Of Community Medicine
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