摘要
目的 探究布地奈德联合沙丁胺醇雾化吸入对支气管哮喘急性发作患者血清中HMGB1的影响,并评价临床治疗效果。方法 分析2013年1月~2014年12月我院收治的支气管哮喘急性发作期患者的临床资料,随机分为两组,观察组患者在采用常规治疗方案外,增加布地奈德联合沙丁胺醇雾化吸入治疗,对照组患者采用常规方法治疗。结果 两组研究对象治疗后肺功能指标FEV_1、FVC、PEF水平明显高于治疗前指标水平,差异具有统计学意义（P〈0.05）;治疗后观察组患者FEV_1、FVC、PEF水平高于对照组患者治疗后的指标水平,差异具有统计学意义（P〈0.05）;治疗后观察组患者血清中血清中TNF-α、CRP、HMGB1水平明显低于对照组,差异具有统计学意义（P〈0.05）;观察组患者HMGB1与FEV_1（r=-0.522,P〈0.001）呈显著负相关,与CRP（r=0.365,P=0.009）呈现正相关关系;观察组患者治疗总有效率为94%,对照组总有效率为79.55%,观察组治疗总有效率明显高于对照组,差异具有统计学意义（P〈0.05）。结论 通过布地奈德联合沙丁胺醇联合雾化吸入治疗支气管哮喘急性发作的患者治疗效果较好,临床上可以大力推广。
Objective To study the effect of budesonide combined with salbutamol aerosol inhalation on HMGB1 in patients with bronchial asthma. Methods The clinical data of patients with acute episode of bronchial asthma in our hospital from January 2013 to December 2014 were randomly divided into two groups： the observation group （budesonide combined with salbutamol aerosol inhalation）, and the control group （conventional treatment）. Results After the treatment, their lung function indexes （FEV1 and FVC）, and PEF level increased significantly （P 〈0. 05）. The levels of FEV1 , FVC and PEF were obviously higher in the observation group than in the control group after the treatment （ P 〈 0. 05 ）, and they showed significant difference before and after the treatment （ P 〈 0.05 ）. The levels of serum TNF-α, CRP and HMGBI were significantly lower in the observation group than in the control group （P 〈0. 05）. In the observation group, HMGB1 was negatively correlated with FEV1 （ r =0. 522, P 〈 0. 001 ）, and positively correlated with CRP （ r = 0. 365, P = 0. 365 ）. The total effective rate was 94% in the obser- vation group and 79. 55% in the control group （P 〈 0.05）. Conclusion Budesonide combined with salbutamol atomization inhalation has good curative effect in the treatment of patients with bronchial asthma.
出处
《临床肺科杂志》
2016年第5期805-808,共4页
Journal of Clinical Pulmonary Medicine
关键词
支气管哮喘
布地奈德
沙丁胺醇
雾化吸入
bronchial asthma
budesonide
salbutamol
atomization inhalation
