摘要
目的探讨急性高原暴露及短期习服对健康青年男性血小板的影响。方法依据纳入和排除标准于2012年6月-2013年8月在成都分别纳入世居成都(海拔500m,平原组,n=193)、由成都(海拔500m)乘飞机2h内进驻拉萨(海拔3700m)后暴露1d(急性高原暴露组,n=147)和7d(短期习服组,n=122)的健康青年男性志愿者。收集志愿者的人口学资料和生理参数,采集血常规及血清学中血小板相关参数,比较3组间血小板相关参数的差异。结果与平原组比较,急性高原暴露组血小板计数(PLT)、血小板分布宽度(PDW)、血小板压积(PCT)降低,平均血小板体积(MPV)升高(P<0.05)。短期习服组上述指标均趋于恢复平原水平,但PLT、PDW、PCT与平原组比较差异仍有统计学意义(P<0.05);急性高原暴露组血小板活化因子(PAF)、肾上腺素(Epi)明显低于平原组(P<0.05),而与急性高原暴露组比较,短期习服组PAF又上升至平原水平,Epi进一步下降(P<0.05)。五羟色胺(5-HT)在3组间比较差异无统计学意义(P>0.05)。Pearson相关性分析结果提示PLT与外周血氧饱和度(SpO_2)呈正相关(P<0.05)。结论急性高原暴露后PLT、PDW、PCT的改变可能与SpO_2降低有关;短期习服后,机体能够逐渐代偿急性高原暴露导致的血小板改变。
Objective To explore the effect of high altitude exposure and short-term acclimation on the platelet-associated parameters by studying the changes of platelet-associated parameters in healthy young man. Methods Four hundred and sixtytwo young men were recruited from Chengdu（the elevation of 500 m） during Jun. 2012 to Aug. 2013 according to the inclusion and exclusion criteria, of which 193 had been living in Chengdu（plain group）, and 269 flew from Chengdu to Lhasa（3700 m） in 2 hours, and then 147 of them were exposed in the high altitude for 1 day（acute high altitude exposure group）, and another 122 for 7 days（short-term acclimation group）. The demographic data were collected and the blood routine and platelet-associated parameters were measured of all the participants, and then the information collected were compared between the 3 groups. Results Compared to the plain group, the platelet count（PLT）, platelet distribution width（PDW） and plateletcrit（PCT） reduced and the mean platelet volume（MPV） increased significantly（P0.05） in the acute high altitude exposure group; while all the indexes in short-term acclimation group returned to approach the levels in the plain group, but statistical differences still existed in PLT, PDW and PCT（P0.05）. The platelet activating factor（PAF） and epinephrine（Epi） decreased markedly in acute high altitude exposure group than in plain group（P0.05）; while in short-term acclimation group, the PAF returned to approach the level in plain group, and the Epi was further down（P0.05）. In addition, no marked difference of 5-HT level was observed in the 3 groups（P0.05）. Pearson correlation analysis indicated that high altitude-induced reduction of oxygen saturation（SpO_2） was positively related to the changes of PLT. Conclusions Acute high altitude exposure may reduce PLT, PDW and PCT levels, but elevate MPV and enhance the platelet activity. The reduction of SpO_2 might be associated with the changes of PLT, PDW and PCT. Platelet-associated parameters may be recovered to normal with a compensatory effect after short-term acclimation.
作者
柯景彬
李佳蓓
张继航
卞士柱
杨杰
刘川
陈灿
张辰
余洁
晋军
黄岚
KE Jing-bin, LI Jia-bei, ZHANG Ji-hang, BIAN Shi-zhu, YANG Jie, LIU Chuan, CI-IEN Can, ZHANG Chen, YU Jie, JIN Jun, HUANG Lan(Department of Cardiology, Xinqiao Hospital, Army Medical University, Institute of Cardiovascular Diseases of PLA, Chongqing 400037, Chin)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2018年第3期251-256,共6页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金面上项目(81470300)
国家自然科学基金重点项目(81730054)
关键词
高原
习服
血小板
血小板活性
high altitude
acclimation
platelet
platelet activity
