摘要
目的探讨烯脂酰辅酶A水合酶短链1(enoyl-coenzyme A hydratase,short chain1,ECHS1)和细胞增殖核抗原Ki-67在结直肠癌组织中的表达及其与临床病理特征的关系。方法选择2013年1月至2016年12月秦皇岛市第一医院肿瘤科收治的50例结直肠癌患者手术切除的组织标本,以10例癌旁组织作为对照,采用免疫组织化学SP法检测结直肠癌组织及癌旁组织中ECHS1和Ki-67的表达,并分析其与临床病理学特征的关系。结果 ECHS1和Ki-67在结直肠癌组织中的阳性表达率分别为56.0%(28/50)和62.0%(31/50),均显著高于癌旁组织中的表达,差异有显著性(P<0.05)。ECHS1和Ki-67的异常表达与结直肠癌的Dukes分期、分化程度及有无淋巴转移有关(P<0.05)。ECHS1和Ki-67的表达呈正相关关系(r=0.501,P=0.010)。结论在结直肠癌组织中ECHS1和Ki-67的表达明显升高,与Dukes分期、分化程度和淋巴转移有关,且二者具有协同作用。
Objective To study the expression of ECHS 1 and Ki-67 in colorectal cancer and clinical significance. Method The expression of ECHS1 and Ki-67 in 42 cases of colorectal cancer, 10 cases of adjacent tissues were examined by immunohistochemistry, analyze the clinical pathological characteristics. Result ECHS1 and Ki-67 in pancreatic cancer tissues were 56.0% （28/50） and 62.0% （31/50）, which were significantly higher than that in paracancerous tissue. The abnormal expression of ECHS 1 and Ki-67 in correlation with the Dukes staging, differentiation and lymph node metastasis （P〈0.05）.The Spearman analysis showed that the level of Sema4D was significantly associated with Ki-67 expression （r=0.501, P〈 0.05）. Conclusion Upregulation of ECHS 1 and Ki-67 expression in pancreatic cancer, both of which have significant correlation, both of which associated with the Dukes staging, differentiationand lymph node metastasis.
作者
陈兰兰
高立明
贾如江
徐淑凤
郑磊
曹军丽
徐红梅
CHEN Lan-lan1, GAO Li-ming1, JIA Ru-jiang2, XU Shu-feng1, ZHENG Lei1, CAO Jun-li1, XU Hong-mei1(1. Department of Oneology, Qinhuangdao First Hospital, Hebei Qinhuangdao 066000, China; 2. First Department of General Surgery, Handan Central Hospital, I-Iebei Handan 056001, Chin)
出处
《中国医刊》
CAS
2018年第3期300-303,共4页
Chinese Journal of Medicine
基金
吴阶平医学基金(320.6750.13340)
