摘要
目的 :观察人参茎叶皂甙 (GSL)促进氟脲嘧啶 (5 FU)对小鼠S1 80实体瘤的抑瘤作用。方法 :采用昆明种小鼠 ,随机分组进行实验 ,分别给予不同剂量人参茎叶皂甙与氟脲嘧啶配伍使用 ,观察其对小鼠S1 80实体瘤抑瘤率的差别。结果 :低剂量人参茎叶皂甙 (1 5mg·kg-1)与氟脲嘧啶 (1 .5mg·kg-1)组方对小鼠S1 80实体瘤有显著的抑瘤作用 (抑瘤率达2 6.90 % ,P <0 .0 5 ) ,对胸腺无抑制作用 ;阳性对照药5 FU(2 5mg·kg-1)的抑瘤率为 3 6.61 % ,但其对胸腺有显著抑制作用 ;而人参茎叶皂甙 (1 0 0mg·kg-1)单用对小鼠S1 80实体瘤抑瘤率为 2 7.44%。结论 :低剂量人参茎叶皂甙 (1 5mg·kg-1)显著促进 5 FU(1 .5mg·kg-1)对小鼠S1 80实体瘤的抑瘤作用而无胸腺抑制作用 ,可并减少 5
AIM: To observe the enhancement of ginsen stem leaves (GSL) to the antitumor effect of 5 FU in mice inoculated S180. METHODS: The different combinations of GSL and 5 FU were used to examine the inhibition rates of tumor growth in KM mice inoculated S180. RESULTS: The combination of GSL (15 mg·kg -1 ) and 5 FU (1.5 mg·kg -1 ) obtained 26.90% of inhibition rates of tumor growth (P< 0.05 ), and did not inhibit the thymus. The antitumor rate of 5 FU (25 mg·kg -1 ) was 36.61%, and the dose markedly decreased the weight of thymus. CONCLUSION: The combination of GSL (15 mg·kg -1 ) and 5 FU (1.5 mg·kg -1 ) can markedly inhibit the tumor growth of S180 in mice, but does not decrease the weight of thymus, suggesting that the combination may decrease the side effect produced by 5 FU.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2002年第4期299-301,共3页
Chinese Journal of Clinical Pharmacology and Therapeutics
