摘要
目的观察茶色素在心肌缺血状态下对离体蟾蜍心肌收缩力、心电图和心率的影响。方法将60只蟾蜍分为正常蟾蜍离体蛙心组(A组)和心肌缺血蟾蜍离体蛙心组(B组),A组再分为林格液组(A1组)、茶色素低剂量(200mg/L)组(A2组)和茶色素高剂量(400mg/L)组(A3组);B组再分垂体后叶素模型组(B1组)、垂体后叶素+茶色素低剂量(200mg/L)组(B2组)和垂体后叶素+茶色素高剂量(400mg/L)组(B3组)。应用BL-420S生物机能实验系统记录蟾蜍离体心肌收缩力和心电图变化曲线。结果与A1组比较,A3组引起心肌收缩力明显增加(P<0.05),A2组差异无统计学意义(P>0.05);心电图QRS峰峰值和心率差异无统计学意义(P>0.05)。与A1组比较,B1组心肌收缩力、心电图QRS峰峰值和心率均明显下降(P<0.05);与B1组比较,B2、B3组心肌收缩力、心电图QRS峰峰值和心率均明显上升(P<0.05)。结论茶色素能明显改善心肌缺血引起离体蟾蜍心脏功能的下降。
Objective To observe the influence of tea pigment on myocardial contractility,electrocardiogram(ECG)and heart rate in exsomatized toads under the condition of myocardial ischemia.Methods Sixty toads were divided into the normal exsoma-tized toad heart group(A)and myocardial ischemia toad heart(B).Then the group A was re-divided into the Ringerrs solution group(A1),tea pigment low dose(200 mg/L)group(A2)and the high dose(400 mg/L)group(A3)the group B was re-divided into the pituitrin model group(B1),pituitrin+tea pigment low dose(200 mg/L)group(B2)and high dose(400 mg/L)group(B3).The BL-420S biological function experiment system was used to record the myocardial contractile force and ECG change curve of exsoma-tized toad.Results Compared with the group A1,the myocardial contractility in the group A3 was obviously increased(P〈0.05),the difference in the group A2 had no statistical significance(P〈〉0.05);the QRS peak value of ECG and heart rate had no statisti-cally significant difference(P〈0.05);compared with the group A1,the myocardial contractility,ECG QRS peak value and heart rate in the group B1 were significantly decreased(P〈0.05)compared with the group B1,the myocardial contractility,ECG QRS peak value and heart rate in the group B2 and B3 were significantly increased(P〈.05).Conclusion Tea pigment can obviously improve the decrease of the exsomatized toad cardiac activity caused by myocardial ischemia.
作者
张毓
戴淑芳
王子丹
孙艺平
傅雷
刘克敏
朱亮
张树龙
ZHANG Yu;DAI Shufang;WANG Zhidan;SUN Yiping;FU Lei;LIU Kemin;ZHU Liang;ZHANG Shulong(College of Basic Medical Science,Dalian Medical University,Dalian,Liaoning 116044,China;Department of Cardiology,Affiliated Zhongshan Hospital of Dalian University,Dalian,Liaoning 116027,China)
出处
《重庆医学》
CAS
2018年第5期588-589,593,共3页
Chongqing medicine
基金
国家自然科学基金资助项目(81370307,81370583)
关键词
茶色素
心肌缺血
心肌收缩力
心电描记术
心率
tea pigment
myocardial ischemia
myocardial contractility
electrocardiography^heart rate
