摘要
用细胞离心器方法,观察胸腺肽对有丝分裂原诱导下小儿胸腺细胞增殖反应影响的形态变化。结果表明,小儿胸腺细胞对PHA刺激反应远较对ConA及PWM刺激反应明显,与小鼠胸腺细胞对ConA刺激反应远较对PHA刺激反应明显有所不同。在体外胸腺肽对小儿胸腺细胞无明显刺激反应;但胸腺肽能分别增强PHA、ConA及PWM诱导下对小儿胸腺细胞增殖反应的作用,尤能增强PHA的刺激作用。
This paper reports a cytocentrifugation study of the morphological changes of mitogen-induced proliferating child thymocytes stimulated by thymus peptides.The proliferation response of child thymocytes to PHA was far more significant than those to ConA and PWN.This differs from the more pronounced effect of ConA on thymocyte proliferation in mice. In vitro, child thymocytes did not respond to thymus peptide without mitogen-induction. However, when thymus peptide was added to thymocyte culture with PHA, ConA, or PWN, proliferation responses were significantly enhanced, being most marked in the PHA-induced cell culture.The mechanism of the enhancing effect of thymus peptide on mitogen-induced human thymocytes is discussed.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1991年第3期168-170,共3页
Acta Academiae Medicinae Sinicae
关键词
胸腺肽
有丝分裂原
胸腺细胞
增殖
thymus peptide cytocentrifugation mitogen child thymocyte proliferation
