摘要
目的 在注射吸毒者、MSM、暗娼和性病门诊男性就诊者中开展HIV-1新发感染检测，估算新发感染率，了解艾滋病在4类人群中的流行趋势。方法 收集2011-2015年四川省注射吸毒者、MSM、暗娼和性病门诊男性就诊者监测哨点的确证阳性样本，排除既往感染后，采用BED-CEIA方法进行新发感染检测，估算4类人群的HIV-1新发感染率。结果 2011-2015年4类人群共计监测194 223例，检出HIV-1阳性5 297例，完成BED-CEIA检测4 640例，判为新发感染749例。MSM、暗娼、性病门诊男性就诊，凉山州3个吸毒哨点（主要为彝族聚居地）监测的注射吸毒者、凉山州外地区吸毒哨点监测的注射吸毒者HIV-1新发感染率分别为5.16%（95% CI：4.65~5.66）、0.22%（95% CI：0.16~0.28）、0.57%（95% CI：0.45~0.69）和7.53%（95% CI：6.06~9.01）、0.44%（95% CI：0.36~0.53）。经χ2检验，各年新发感染率差异均有统计学意义。结论 2011-2015年凉山州外地区的注射吸毒者、暗娼和性病门诊男性就诊者新发感染率均保持在较低的水平，防治工作取得一定成效。MSM的HIV-1新发感染率较高，且存在上升趋势，不排除HIV由MSM向其他高危人群扩散的可能。
Objective Data from the HIV/AIDS surveillance sentinel sites was used to identify the recent HIV-1 infections and to estimate the HIV-1 incidence and epidemic trends among intravenous drug users （IDU）, MSM, female sex workers and men attending the sexually transmitted disease clinics in Sichuan province.Methods Specimens collected from IDUs, MSM, female sex workers and men attending the sexually transmitted disease clinics sentinel sites were confirmed as HIV-1 positive and tested with BED-CEIA. Annual HIV-1 prevalence and incidence rates were calculated and the incidence was adjusted by McNermar method.Results A total number of 194 223 serum specimens were collected and HIV antibody tested, with 5 297 HIV-1 positive. 4 640 of the positives underwent BED-CEIA, with 749 identified as recent infections. During 2011-2015, HIV-1 incidence rates of the four types of population appeared as 5.16% （95% CI：4.65-5.66）, 0.22% （95% CI：0.16-0.28）, 0.57%（95% CI：0.45-0.69）, 7.53% （95% CI：6.06-9.01） and 0.44% （95% CI：0.36-0.53） respectively. Significant differences were seen in the HIV-1 incidence rates.Conclusions The HIV-1 incidence rates of IDUs from other sentinel sites in Sichuan province, female sex workers and men attending the sexually transmitted disease clinics appeared low, showing that the AIDS prevention and control activities worked effectively. However, the HIV-1 incidence of MSM was still at high level and even rising, suggesting that HIV-1 transmission between MSM and IDUs was possible.
出处
《中华流行病学杂志》
CAS
CSCD
北大核心
2017年第12期1649-1654,共6页
Chinese Journal of Epidemiology
基金
四川省卫生厅科研课题（130003）
