摘要
目的了解2018年~2020年昆明市通过社会组织新报告的HIV-1感染男男性行为人群(men who have sex with men,MSM)的新近感染情况和影响因素,为该人群的艾滋病防治提供参考。方法对昆明市2018年1月至2020年12月经抗体筛查和确证检测后的MSM阳性样本采用HIV-1限制性抗原亲和力酶联免疫方法(HIV-1 LAg-Avidity enzyme immunoassay,LAg-Avidity EIA)结合CD4+T淋巴细胞计数判断新近感染,采用Logistic回归分析新近感染影响因素。结果共收集389份阳性样本,2018年1月至2020年12月HIV-1新近感染者比例分别为48.1%(90/187)、51.6%(49/95)、30.8%(33/107),2018年1月和2019年12月的新近感染比例,差异无统计学意义(P>0.05),2020年的新近感染比例低于2018年和2019年(P<0.05)。多因素Logistic回归分析显示职业为学生(P=0.017,OR=2.989,95%CI:1.221~7.318)检测出新近感染的比例高。结论昆明市MSM人群HIV-1新近感染的比例出现下降趋势,在部分人群中新近感染的比例较高,需要有针对性地采取措施,加强新近感染的监测,通过社会组织加强干预服务的可及性,进一步促进检测。
Objective To understand the recent infection status and influencing factors of HIV-1 infected men who have sex with men(MSM)newly reported by non-governmental organizations(NGO)in Kunming city from January 2018 to December 2020,and to provide guidance for AIDS prevention and treatment for this population.Methods The limiting-antigen avidity enzyme immunoassay(LAg-Avidity EIA)combined with CD4+T lymphocyte count was used to determine the recent infections among HIV-1 antibody positive MSM in Kunming city from January 2018 to December 2020.The influencing factors of recent infections were analyzed by Logistic regression.Results A total of 389 HIV-1 antibody positive samples were collected,and the proportion of HIV-1 recent infections was 48.1%(90/187),51.6%(49/95)and 30.8%(33/107)from January 2018 to December 2020.There was no statistical difference in the proportion of recent infections between 2018 and 2019(P>0.05).The proportion of recent infections in 2020 was lower than those in 2018 and 2019(P<0.05).Multivariate Logistic regression analysis showed that students(P=0.017,OR=2.989,95%CI:1.221~7.318)had a high proportion of recent infections.Conclusion The proportion of HIV-1 recent infection among MSM in Kunming showed a decreasing trend,and the proportion of recent infection was relatively higher in the certain population.The targeted measures should be taken,including strengthening the monitoring of recent infections among MSM,improving access to intervention services and promoting HIV testing through NGO.
作者
曹瑞
徐畅
金晓媚
戴洁
陈会超
董莉娟
杨敏
杨莉
陈敏
CAO Rui;XU Chang;JIN Xiaomei;DAI Jie;CHEN Huichao;DONG Lijuan;YANG Min;YANG Li;CHEN Min(School of Public Health,Kunming Medical University,Kunming Yunnan 650500;School of Public Health,Fujian Medical University,Fuzhou Fujian 350122;Yunnan Provincal AIDS Research Institute,Yunnan Center for Disease Control and Prevention,Kunming Yunnan 650022,China)
出处
《昆明医科大学学报》
CAS
2022年第8期150-155,共6页
Journal of Kunming Medical University
基金
云南省科技人才和平台计划基金资助项目(2019HB053)。
关键词
HIV
新发感染
男男性行为者
HIV
Recent infection
Men who have sex with men
