摘要
含氮杂环是很多天然产物、生物医药活性物种、光电新材料等的重要结构单元,也是有机合成中非常重要的合成子.主要介绍金催化分子间炔烃与氮烯前体的反应,合成多取代氮杂环化合物.在该类反应中,炔烃经金催化剂活化后,与各种不同的氮烯前体反应,以一种高效、快捷的转化模式构建多官能团化的含氮杂环化合物.
N-Heterocyclic rings are versatile structural units that widely dispersed in a variety of natural products,biological active species,and photoelectric materials.They are also useful building blocks in synthetic community.This review mainly focused on recent progress on gold-catalyzed intermolecular nitrene transfer reactions with alkynes.This strategy complements the toolbox for the synthesis of multisubstituted N-heterocyclic compounds.Mechanistically,activated by a suitable gold catalyst,the specific alkyne could react with a nitrene precursor,providing the final N-heterocyclic compounds in highly efficient manner.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第11期2785-2799,共15页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.2142197
21502190)
福建省自然科学基金(No.2017J0131)资助项目~~
关键词
金催化
炔酰胺
氮烯前体
含氮杂环
α-亚胺金卡宾
gold-catalysis
ynamide
nitrene precursor
N-heterocycle
a-imino-gold-carbene
