摘要
金催化剂由于具有高反应性、独特选择性、对π键的高亲和力等优点,通常用于活化炔烃、烯烃和联烯等化合物.其中,金催化剂不仅能够活化炔烃形成乙烯基金中间体或者金卡宾中间体参与反应,而且也能够催化炔烃发生分子内环化构建新型杂环或多环化合物.此综述总结了近八年来金催化炔烃的分子内环化反应,包括不同亲核性的碳原子和杂原子与炔烃的分子内环化反应,及其在天然产物全合成领域方面的应用.
As gold catalysts have the advantages of high reactivity,unique selectivity,and high affinity forπbonds,they are usually used to activate alkynes,alkenes,and allenes.Gold catalysts not only promote the activation of alkynes to form vinyl gold intermediates or gold carbene intermediates to participate in the reaction,but also catalyze the intramolecular cyclization to form new types of heterocycles or polycyclic compounds.This review summarizes the gold-catalyzed intramolecular cyclization of alkynes in recent eight years,including the intramolecular cyclization of different nucleophilic carbon-atom and heteroatoms,and its applications in the total synthesis of natural products.
作者
张旭
邹佩森
刘小清
闭红艳
莫冬亮
Zhang Xu;Zou Peisen;Liu Xiaoqing;Bi Hongyan;Mo Dongliang(State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources,School of Chemistry and Pharmaceutical Sciences,i Normal University,Guilin,Guangx 541004)
出处
《有机化学》
北大核心
2025年第10期3755-3776,共22页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.22071036)
广西自然科学基金(No.2023GXNSFDA026025)
广西八桂青年学者资助项目。
关键词
金催化
炔烃
分子内环化反应
杂环化合物
反应选择性
gold catalysis
alkynes
intramolecular cyclization
heterocyclic compounds
reaction selectivity
