摘要
IgA肾病被认为是一种免疫介导的炎症性疾病,但其发病及进展机制尚未完全明确。目前认为IgA肾病的可能机制为糖基化缺陷的IgA1增多,与抗聚糖抗体结合为免疫复合物,沉积于肾小球系膜区,进而激活补体途径,导致免疫炎症反应。补体激活的替代途径、凝集素途径、补体成分以及补体调节蛋白在IgA肾病的发病及进展过程中发挥重要作用。肾组织、尿液、血清中补体成分及其调节因子的检测可望作为IgA肾病病情活动及判断预后的标志物。全基因组关联分析等新技术手段的应用有助于深入研究IgA肾病中补体系统的作用及机制,使其成为IgA肾病新的治疗靶点。
Although immunoglobulin A （IgA） nephropathy （IgAN） is considered as an immune-mediated inflammatory disease,the pathogenesis and mechanisms associated with its progression have not been completely understood. To date,the potential pathogenesis of IgAN is thought to be a possible increase of galactose-deficient IgA1 ,followed by binding to antiglycan antibodies to form immune complexes, which are deposited in the glomerular mesangium and lead to the activation of complement pathways and initiation of immune-mediated inflammation. Activation of alternative and leetin complement pathways, complement components, and complement regulatory proteins play important roles in the pathogenesis and progression of IgAN. Complement components and complement regulatory factors in the renal tissue, urine, and serum samples are considered to be useful predictive hiomarkers to evaluate the activation of the complement system and determine the prognosis of IgAN . The application of novel techniques such as the genome-wide association study would promote further research to determine the role and mechanisms of action of the complement system,whereby it could be used as a new therapeutic target for the management of IgAN.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2017年第12期1133-1137,共5页
Journal of China Medical University
基金
国家自然科学基金(81500525)
辽宁省自然科学基金(2014021046)
关键词
IGA肾病
补体系统激活
immunoglobulin A nephropathy
complement systems activation
