摘要
C3肾小球病(简称C3肾病)主要是由于补体旁路途径调节异常导致补体旁路途径过度活化,C3沉积于肾小球毛细血管壁而致病。补体旁路途径的实验室检查结果,包括补体途径的活性测定、补体成分的自身抗体检测、补体成分及调节蛋白的定量检测和补体旁路途径先天遗传的基因检测等将对C3肾病的诊断和鉴别诊断提供重要参考。
C3 glomerulopathy is mainly caused by the dysregulation of alternative complement pathwa）5 which results in the over activation of this pathway and subsequent glomerular injuries. Laboratory detections will be very helpful for the precise diagnosis of C3 glomerulopathy. Current available tests include functional complement assays, screening for autoantibodies against complement components, quantitation of complement components and regulatory proteins, and tests for genetic mutations or deficiencies in complement proteins.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2017年第9期786-789,共4页
Chinese Journal of Practical Internal Medicine
关键词
C3肾小球病
补体旁路途径
实验室检测
C3 glomerulopathy
altemative complement pathway
laboratory tests
