摘要
用心脏程控刺激技术(PES),研究了ⅳ槐定对慢性心肌梗塞犬的正常心肌和梗塞心肌的电生理及快速室性心律失常的影响,并与普鲁卡因胺对比。两药均可显著延长OTc间期,RERP,NERP及IERP,缩小IDR和VDR,提高DET,抑制PES诱发的VT或VF,槐定尚可预防犬心肌梗塞后由急性心肌缺血所致的自发性室颤,证实了槐定抗缺血性快速室性心律失常的作用。
The effects of sophoridine (Sop, 30 mg / kg iv) on ischemic ventricular tachyarrhythmias and electrophysiologic consequences in both normal and ischemic myocardium were studied in the open+chest dogs subject to programmed electrical stimulation (PES) oh 5-8 d after acute myocardial infarction. Its effects were compared with those of procainamide (PA 25 mg / kg iv). Both drugs distinctly lengthened the QTc interval and the effective refractory period (ERP) of the normal and infarct myocardium in both ventricles, decreased the dispersion of ERP in infarct myocardium (IDR) as well as the dispersion of ERP in left ventricle (VDR) and increased the diastolic excitability threshold(DET) of the normal and infarct myocardium in both ventricles remarkably. The PES-induced ventricular tachycardia (VT) or ventricular fibrillation (VF) was prevented in the 5 out of the 6 Sop and PA treated dogs respectively. Sop prevented spontaneous VF in 5 dogs (n = 6); PA prevented spontaneous VF in 4 dogs (n = 6); normal saline (NS) did not prevented PES-induced VT or VF and spontaneous VF. The results suggested that Sop might be effective in preventing the onset of reentrant ventricular tachyarrhythmias and sudden coronary death after myocardial ischemic damage.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
1991年第2期104-107,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
槐定
心肌梗塞
心律失常
药理
sophoridine
myocardial infarction
arrhythmia
ischemia
procainamide
