摘要
在氯化铯引起的兔触发性心律失常模型上，通过单相动作电位（Monophasicactionpotential，MAP）测定，观察了槐定和硫酸镁对触发性心律失常的抑制作用。结果显示：（1）静脉注射氯化铯后QT间期延长，心律减慢，单相动作电位90％复极间期（MAPD90）延长，出现早期后除极（Earlyafterdepolarization，EAD），由EAD诱发心律失常，发生率100％，其中室性心动过速为50％。（2）静脉注射槐定和硫酸镁后，EAD振幅（EADA）均减小，心律失常发生率分别为30％和25％（与对照组比两者均P＜0．05），无一例发生室性心动过速。
The effects of Sophoridine (Soph)and Magnesium Sulfate (MgSO4 )on early afterdepolarization(EAD)and triggered arrhythmlas were investigated through monophasic action potential (MAP) measurement in rabbit models of cesium-induced arrhythmia. The resultsshowed: <1> In control group cesium chloride injection prolonged QT interval; decreasedheart rate (HR) ; increased MAP duration at 90% repolarization (MAPD90) and developedEAD. All the animals developed ventricular arrhythmia and 50% of them developed ventricular tachycardia. <2>Sophoridine or MgSO4 administration before cerium injection decreasedthe amplitude of EAD and reduced triggered arrhythmia and completely prevented cesium-in-duced ventricular tachycardia (Vs control group P<0. 05 respectively).
出处
《江西医学院学报》
CAS
1998年第3期41-44,共4页
Acta Academiae Medicinae Jiangxi
关键词
心律失常
动作电位
早期后除极
槐定
MAP
EAD
硫酸镁
arrhythmia
action potentials
early afterdepolarization,sophoridine
magnessium sulfate
