摘要
用宏观放射自显影术研究[^(14)C]乙双吗啉在小鼠体内的分布。药物经尾静脉注射后很快分布到各组织,以肺、肾、肝及胃肠道聚积的放射性为最高。其次为肿瘤及皮肤等组织,而大脑内未见有放射性分布。
Distribution of 〔14C〕 bimolane in mice was studied by means of whole body autoradiography. At 30min, and lh, 3h, 9 h, 24h after iv, the mice were briefly anesthetized with ether and frozen by immersing indry ice/acetone. The mice were processed for whole body auto-radiography by continual sections with LKB-2250 PMV big whole body automatic-manual frozen cutter. The exeriments showed that 〔24C〕 bimolane distributed rapidly into the various tissues after iv administrtion. The highest radioactivity was found in lung, kidney, gastrointestinal tract, then the tumor, skin etc, the lowest radioactivity was found in brain.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第1期50-52,共3页
Chinese Pharmacological Bulletin
关键词
乙双吗啉
放射自显影
〔^(14)C〕 Bimolane
Whole body autoradiography
Tissue distribution
Specifie activity
l4C-label
Radioactivity concentratien
