摘要
目的评价血清乳酸脱氢酶水平对小细胞肺癌患者的预后影响。方法计算机检索PubMed、Embase、万方等数据库,并从符合纳入标准的文献中查找相关文献。对符合入选条件的文献数据进行Meta分析。结果纳入8个研究共1 671例小细胞肺癌患者。血清乳酸脱氢酶浓度高水平对患者的危害是低水平的1.25倍[95%CI(1.10,1.42),P=0.000]。结论治疗前血清乳酸脱氢酶浓度高水平的小细胞肺癌患者预后总生存率较低水平患者差,其水平对小细胞肺癌预后有一定的预测价值。
Objective To evaluate the prognostic impact of serum lactate dehydrogenase （LDH） level in patients with small cell lung cancer. Methods PubMed, Embase, Wanfang databases were searched for relevant studies thatassessed the prognostic relevance of serum LDH. Meta-analyses were conducted to estimate the summary incidence. Results A total of eight studies comprising of 1 671 patients met the inclusion criteria. Patients with high LDH levels were 1.25 times[95% CI （1.10,1.42） ,P = 0. 000 ] more at risk compared to those with low levels of LDH. Conclusion Patients with high levels of pre-treatment LDH have worse overall survival prognosis compared to those with low LDH levels, and LDH levels have predictive value to patients with small cell lung cancer.
出处
《实用肿瘤杂志》
CAS
2014年第1期48-51,共4页
Journal of Practical Oncology
关键词
癌
小细胞
乳酸脱氢酶
预后
综合分析
carcinoma, small cell
lactate dehydrogenase
prognosis
Meta-analysis
