摘要
目的探讨出生至矫正6月龄早产儿体格生长规律,为早产儿保健提供指导。方法对786例有完整随访资料的早产儿进行分析,所有研究对象均进行早期综合干预,定期随访至矫正6月龄。按出生胎龄(<32、32~33+6、34~35+6、36~36+6周)和出生体重与胎龄关系(小于、适于、大于胎龄儿)分别进行分组,使用混合效应模型分析早产儿体重、身长和头围的变化趋势。结果四组不同出生胎龄早产儿体重、身长和头围的组间效应(F值分别为11.88、29.91、19.19)和时点效应(F值分别为7 678.78、11 922.57、7 913.78)的差异有统计学意义(P均<0.001);小于、适于和大于胎龄儿体重、身长和头围的组间效应(F值分别为88.01、79.36、50.27,P均<0.001)和时点效应(F值分别为1 192.38、1 836.58、1 225.71)的差异有统计学意义(P均<0.001)。矫正6月龄时,50%以上早产儿的三项指标处于我国足月儿参考值的第25至75百分位。结论早产儿的体格生长与出生胎龄和体重密切相关,早期综合干预可促进早产儿体格生长。
Objective To explore physical growth of premature infants under corrected age of 6months and to provide guidance on health care for premature infants. Methods A total of 786 premature infants with complete follow-up data were enrolled.All premature infants were offered early comprehensive intervention and followed up until corrected age of 6months.Premature infants were divided into different groups according to gestational age（32、32~33＋6、34~35＋6、36~36＋6 weeks）and the relationship between gestational age and birth weight（small,appropriate and large for gestational age）,respectively.Linear mixed model was used to assess changes in physical growth of premature infants. ResultsWeight,length and head circumference among different gestational age groups（Fvalues were 11.88,29.91 and 19.19,respectively）and different corrected age points（Fvalues was 7678.78,11922.57 and 7913.78,respectively）were significantly different（all P0.001）;Significant difference was also found on weight,length and head circumference among SGA,AGA and LGA infants（Fvalues were 88.01,79.36 and 50.27,respectively,all P0.001）and different corrected age points（F values were 1 192.38,1 836.58 and 1 225.71,respectively,all P0.001）.At corrected age of 6months,more than 50% of premature infants were between the 25 th and the 75 th percentices of Chinese full-term infant reference. Conclusions Physical growth of premature infants is closely related to gestational age and birth weight.Early comprehensive intervention has positive effect on promoting physical growth of premature infants.
作者
王雪茵
赵更力
周敏
张小松
王旭
郝波
WANG Xue-yin ZHAO Geng-li ZHOU Min ZHANG Xiao-song WANG Xu HAO Bo(Department of Gynecology and Obstetrics ,Peking University First Hospital ,Beijing 100034 ,China)
出处
《中国儿童保健杂志》
CAS
2017年第10期1002-1005,1011,共5页
Chinese Journal of Child Health Care
基金
国家卫生和计划生育委员会妇幼健康服务司委托:早产(儿)干预研究项目(2011-2014)
关键词
早产儿
体格生长
随访研究
早期干预
premature infants
physical growth
follow-up study
early intervention
