摘要
目的:探讨富血小板血浆在膝关节骨关节炎治疗中的应用效果。方法:选择2015年1月至2016年12月门诊收治67例膝关节骨关节炎患者,通过随机分组法分成玻璃酸钠腔内注射对照组(34例)和富血小板血浆腔内注射实验组(33例),比较两组患者总体治疗有效率,以及两组患者治疗前、治疗后一个月、六个月Lysholm膝关节功能评分和VSA疼痛程度评分变化情况。结果:实验组与对照组患者临床总有效率比较,高于对照组,且多为治愈,差异具有统计学意义(P<0.05)。治疗前两组患者Lysholm膝关节功能评分差异不具有统计学意义(P>0.05);治疗后实验组患者Lysholm膝关节功能评分上升更多,差异显著,具有统计学意义(P<0.01),治疗后6个月两组患者Lysholm膝关节功能评分均有所回落,对照组评分降至与注射前相近,而实验组虽有降低,但仍优于注射前评分,两组评分差异具有统计学意义(P<0.05)。治疗前两组患者VSA疼痛程度评分差异无统计学意义(P>0.05);治疗后1个月两组患者VSA疼痛程度评分均有明显下降,实验组患者VSA疼痛程度评分下降更明显,两组评分差异具有统计学意义(P<0.05),治疗后6个月两组患者VSA疼痛程度评分均有回升,但仍然低于注射前VAS评分,两组评分差异具有统计学意义(P<0.05)。结论:采用富血小板血浆腔内注射进行治疗膝关节骨关节炎相对于玻璃酸钠腔内注射法有效率更高,膝关节功能恢复更佳,可以有效减轻患者的疼痛程度且有效时间更长,值得临床推广,具有可借鉴性。
Objective： To investigate the effect of platelet-rich plasma in the treatment of knee osteoarthritis.Methods： 67 Patients with osteoarthritis of the knee were selected from January 2015 to December 2016.The patients were divided into sodium hyaluronate injection control group （34 cases） and platelet-rich plasma injection group （33 cases）.The scores of Lysholm knee function scores and VSA pain scores were compared between the two groups before and after treatment.Results： Compared with the control group,the total effective rate of the patients was significantly higher than that of the control group,and the difference was significant （P〈0.05）.The difference of Lysholm knee function scores between the two groups before treatment was no significant （P〉0.05）.After 1 months of treatment,the Lysholm knee function scores increased significantly,and the difference was significant （P〈0.01）.After 6 months of treatment,Lysholm knee function scores were down,the control group scores fell as that before injection.While the experimental group,although reduced,but still better than pre-injection score.There was still significant difference between the two groups （P〈0.05）.There was no significant difference of the VSA scores between the two groups （P〈0.05）.After 1 months of treatment,the VSA scores of the two groups were improved,with the VSA scores of experimental group lower than that of the control group （P〈0.05）.But after 6 months of treatment,the VSA scores were significantly decreased in the two groups.The VSA scores of experimental group were still lower than that of the control group,the difference was statistically significant （P〈0.05）.Conclusion： The use of platelet-rich plasma injection for the treatment of osteoarthritis of the knee is more effective than the sodium hyaluronate injection method,with better knee function recovery and more pain remission,and the effective time is longer.It＇s worthy for clinical promotion,with reference.
作者
付立功
陈连旭
FU Ligong CHEN Lianxu(Changchun Hospital, Tsinghua University, Beijing 102218, China)
出处
《河北医学》
CAS
2017年第9期1463-1467,共5页
Hebei Medicine
基金
北京市科技计划项目
(编号:20140954)
