摘要
该试验研究了小鼠酒精性肝损伤模型的建立以及水果酵素对小鼠酒精性肝损伤的保护作用。结果表明,连续白酒灌胃可引起小鼠肝脏损伤,表现为肝脏指数和血清指数升高、肝脏过氧化物含量升高、肝脏抗氧化能力降低以及肝细胞肿胀和脂肪变性等。与模型组相比,不同浓度的水果酵素均可有效恢复肝脏指数、降低血清中谷草转氨酶(GOT)、谷丙转氨酶(ALT)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、丙二醛(MDA)水平,提高高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)水平。病理学观察结果显示肝脏脂肪变性得到改善,肝脏细胞排列较为整齐,组织结构趋于正常,说明水果酵素可预防和修复酒精对小鼠肝脏的损伤,具有一定的保肝效果。
The establishment of model of alcoholic liver injury in mice and the protective effect of fermented fi＇uit beverage on alcoholic liver injury in mice were researched. Results showed that feeding Baijiu （Chinese liquor） could cause mice liver injury by increasing liver index, serum index and liver peroxide content, decreasing liver antioxidant capacity, hepatocellular swellinge and fatty degeneration. Compared to the model group, different concentrations of fermented fi＇uit beverage could effectively restore liver index, decrease glutamic oxalacetic transaminase （GOT）, alanine transaminase （ALT）, triglyceride （TG）, total cholesterol （TC）, low density lipoprotein cholesterol （LDL-C） and malondialdehyde （MDA） in serum, and increase high density lipoprotein cholesterol （HDL-C）, superoxide dismutase （SOD） and glutathione peroxidase （GSH-Px）. Results of pathological observation showed liver fat degeneration was improved, the liver cells were aligned, the organizational structure tends to be normal, which fermented fruit beverage could prevent and reoair alcoholic liver iniurv in mice, and had certain orotective effect on liver.
出处
《中国酿造》
CAS
北大核心
2017年第9期112-115,共4页
China Brewing
基金
校企合作横向课题(K403021513)
关键词
水果酵素
抗氧化
脂肪代谢
保护作用
fermented fruit beverage
antioxidation
fat metabolism
protective effect
