摘要
目的探讨血清C反应蛋白(CRP)和白细胞介素(IL)-6水平对ST段抬高型心肌梗死(STEMI)患者支架内血栓形成的预测价值。方法选择2013年7月至2014年7月在该院确诊为STEMI患者120例,所有患者均行经皮冠状动脉介入术(PCI),术后2h抽血,采用酶联免疫吸附试验检测患者血清CRP和IL-6水平,并随访患者,探讨不同血清CRP和IL-6水平与患者PCI术后血栓形成、冠状动脉血流及临床预后的关系。结果高水平CRP和IL-6患者急性血栓、亚急性血栓、1年内血栓、2年内血栓发生率明显高于对应的低水平患者,差异有统计学意义(P<0.05)。低水平CRP患者收缩期峰流速(SPV)、舒张期峰流速(DPV)、时间速度积分(CTVI)及冠状动脉血流储备(CFVR)分别为(15.8±3.9)cm/s、(33.9±5.1)cm/s、21.7±2.8、3.9±1.8,明显高于高水平CRP患者;低水平IL-6患者SPV、DPV、CTVI、CFVR分别为(15.3±3.2)cm/s、(32.5±5.6)cm/s、20.4±2.1、3.8±1.1,明显高于对应的高水平IL-6患者。高水平CRP患者PCI术后心肌梗死的发生率为21.7%,术后1年、术后2年主要心脏事件(MACE)发生率分别为30.0%、36.7%,明显高于低水平患者,差异有统计学意义(P<0.05)。高水平IL-6患者PCI术后心肌梗死的发生率为20.0%,术后1年、术后2年MACE发生率分别为31.6%、38.3%,明显高于低水平患者,差异有统计学意义(P<0.05)。结论高水平CRP和IL-6患者支架内血栓形成风险高、预后差。
Objective To investigate the predictive value of serum CRP and IL-6 levels for stent thrombosis in the patients with ST segment elevation myocardial infarction（STEMI）.Methods One hundred and twenty cases of STEMI in our hospital from July2013 to July 2014 were selected and underwent PCI surgery.Blood collection was performed at postoperative 2h.Serum CRP and IL-6levels were detected by adopting the enzyme-linked immunosorbent assay（ELISA）.The stent thrombosis,coronary blood flow and clinical prognosis were followed up after PCT.The relationship between different serum CRP and the IL-6 levels with thrombosis,coronary blood flow and clinical prognosis after PCI was investigated.Results The occurrence rates of acute thrombosis,subacute thrombosis,thrombosis within 1 year and thrombosis within 2 years in the patients with high CRP and IL-6 levels were significantly higher than those in the patients with corresponding low levels,the differences were statistically significant（P0.05）.SPV,DPV,CTVI and CFVR in the patients with low CRP level were（15.8±3.9）cm/s,（33.9±5.1）cm/s,21.7±2.8and 3.9±1.8 respectively,which were obviously higher than those in the patients with high CRP level;SPV,DPV,CTVI and CFVR in the patients with low IL-6 level were（15.3±3.2）cm/s,（32.5±5.6）cm/s,20.4±2.1 and 3.8±1.1respectively,which were significantly higher than those in the patients with high IL-6 level.The occurrence rate of postoperative myocardial infarction（MI）in the patients with high CRP level was 21.7%.The main adverse cardiac events（MACE）at postoperative 1,2years were 30.0% and36.7% respectively,which were significantly higher than those in the patients with low level,the difference was statistically significant（P0.05）.The occurrence rate of postoperative MI in the patients with high IL-6 level was 20.0%,MACE at postoperative 1,2 years were 31.6% and 38.3% respectively,which were significantly higher than those in the patients with low level,the difference was statistically significant（P0.05）.Conclusion The patients with high CRP and IL-6 levels have high risk of stent thrombosis and poor prognosis.
出处
《检验医学与临床》
CAS
2017年第17期2534-2536,共3页
Laboratory Medicine and Clinic
