摘要
目的观察血清C反应蛋白(CRP)、白细胞介素-18(IL-18)在急性心肌梗死(AMI)患者中的表达,并分析二者与经皮冠脉介入术(PCI)治疗效果的关系。方法选取2017年7月至2021年7月商丘市第一人民医院收治的106例AMI患者为研究对象,患者均接受PCI治疗,且术后获得1个月随访。随访1个月时,通过冠状动脉造影检查评估患者冠状动脉管腔狭窄情况,并将其分为有效组与无效组。检测患者PCI术前血清CRP、IL-18水平,记录患者基线资料,分析血清CRP、IL-18水平与AMI患者PCI治疗效果的相关性。结果106例接受PCI术的AMI患者经评估,26例治疗无效,占24.53%;无效组PCI术前血清CRP、IL-18水平均高于有效组(P<0.05),组间其他基线资料比较,差异无统计学意义(P>0.05);logistic回归分析结果显示,PCI术前血清CRP、IL-18过表达与AMI患者接受PCI术无效存在一定联系(P<0.05)。结论PCI术前血清CRP、IL-18过表达与AMI患者PCI治疗无效存在一定联系。
Objective To observe the expression of serum C-reactive protein(CRP)and interleukin-18(IL-18)in patients with acute myocardial infarction(AMI),and to analyze the relationship between the two and therapeutic effect of percutaneous coronary intervention(PCI).Methods A total of 106 patients with AMI treated in Shangqiu First People’s Hospital from July 2017 to July 2021 were selected as the research subjects.All patients underwent PCI,and the results of the follow-up one month after the operation of the patients were obtained.At the follow-up of 1 month,the coronary angiography was performed to evaluate the stenosis of coronary artery lumen of patients,and divided into effective group and ineffective group.The levels of serum CRP and IL-18 of patients before PCI were measured,the baseline data of patients were recorded,the correlation between the levels of serum CRP and IL-18 and therapeutic effect of PCI in patients with AMI was analyzed.Results Among 106 AMI patients who underwent PCI,26 patients were ineffective,accounting for 24.53%.The levels of serum CRP and IL-18 in the ineffective group before PCI were higher than those in the effective group(P<0.05).There was no statistical difference in other baseline data between groups(P>0.05).Through logistic regression analysis,the results showed that overexpression of serum CRP and IL-18 before PCI was related to the ineffective treatment of PCI in patients with AMI(P<0.05).Conclusion The overexpression of serum CRP and IL-18 before PCI is related to the ineffective treatment of PCI in patients with AMI.
作者
何耀华
HE Yaohua(Second Department of Cardiology,Shangqiu First People’s Hospital,Shangqiu 476100,China)
出处
《河南医学研究》
CAS
2021年第36期6772-6774,共3页
Henan Medical Research
关键词
急性心肌梗死
经皮冠脉介入术
C反应蛋白
白细胞介素-18
相关性
acute myocardial infarction
percutaneous coronary intervention
C-reactive protein
interleukin-18
correlation
