摘要
目的:基于数据挖掘技术探讨中药复方治疗原发性痛经的用药规律。方法:以中国期刊全文数据库(CNKI)为检索库,检索自2006年6月至2016年6月关于中药复方治疗原发性痛经的相关文献,建立中药复方治疗原发性痛经文献数据库,并采用Excel 2010、SPSS 22.0及SPSS Modeler14.2软件进行频数频率分析、聚类分析、关联分析等。结果:中药复方治疗原发性痛经文献涉及复方74首,涉及76味中药,当归为核心单味中药;涉及高频药物种类以活血化瘀、补血、补气等为主;通过对高频药物等聚类分析可形成5个聚类组合,原发性痛经主要集中在气血亏虚兼血瘀证、肝肾不足兼气滞血瘀证两种证型;通过关联规则分析,共得规则25条,以当归、白芍、川芎、延胡索四味中药两味或多味的组合最为常用。结论:瘀血为导致原发性痛经的直接原因,多属本虚(气虚、血虚、虚寒)标实之证,遣药组方上重视气血同调,肝肾并补、重视和血等治法。
This study was aimed to explore the medication rules of Chinese herbal medicine compound in the treatment of primary dysmenorrheal based on data mining. Relevant literatures on Chinese herbal medicine compound in the treatment of primary dysmenorrhea were retrieved from June 2006 to June 2016 in the Chinese Journal Full-text Database（CNKI） to establish a literature database. The Excel 2010, SPSS 22.0 and SPSS Modeler 14.2 software were used in the frequency analysis, cluster analysis, association analysis, and etc. The results showed that literatures related to Chinese herbal medicine compound in the treatment of primary dysmenorrhea, there were 74 compound formula and 76 kinds of Chinese herbal medicine involved. Angelica was the core single Chinese herbal medicine. Chinese herbal medicine with high-frequency usage was the type of removing blood stasis, invigorating qi and blood. Cluster analysis can form 5 clustering combination. Primary dysmenorrhea was mainly clustered to two syndromes, which were qi and blood deficiency with blood stasis, liver and kidney deficiency with qi stagnation and blood stasis. The association rules analysis showed that there were a total of 25 rules, with the most common combination of two or multiple combination from four kinds of Chinese herbal medicine, including Angelica, Radix Paeoniae Alba, Rhizoma Chuanxiong, and Rhizoma Corydalis. It was concluded that blood stasis was the direct cause of primary dysmenorrhea, many of which belonged to the deficiency of root（i.e., deficiency of qi, blood and cold deficiency） and excess of branch. Chinese herbal medicine treatment should be focused on the regulation of both qi and blood, invigoration of both liver and kidney, as well as harmonization of the blood.
出处
《世界科学技术-中医药现代化》
CSCD
2017年第5期733-739,共7页
Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology
基金
国家中医药管理局中医药行业科研专项(201407001-7):慢性疼痛中医止痛康复技术评价与推广研究
负责人:吕晓东
关键词
原发性痛经
数据挖掘
用药规律
机制探索
Chinese herbal medicine compound
primary dysmenorrhea
data mining
frequency analysis
cluster analysis
association rules analysis
rule
mechanism
