摘要
目的:研究乌药的镇痛和抗炎作用,为其临床应用提供实验依据。方法:采用小鼠热板法和冰醋酸致小鼠疼痛扭体反应研究乌药的镇痛作用;采用棉球致大鼠肉芽肿、二甲苯致小鼠耳廓肿胀、角叉菜胶诱发大鼠足肿胀等模型研究抗炎作用。结果:实验表明,乌药可明显减少小鼠扭体次数,明显降低大鼠肉芽肿、明显降低小鼠耳廓肿胀率、明显降低大鼠足肿胀度。结论:乌药具有明显的镇痛和抗炎作用,具有良好的开发应用前景。
Objective To study analgesic and anti-inflammatory effects of Lindera Radix,provide scientific basis for its clinical application. Methods： The analgesic effect of Linderae Radix was observed by hot plate method and aceti cacid writhing method in mice; The anti-inflammatory effect were evaluated the granuloma model induced by embedding cotton pellet,by the ear edema model of mice induced by xylene and the rat paw edema model induced by carrageenan. Results：Experiments indicated Linderae Radix could obviously decrease mice writhing times; obviously inhibited the granuloma hyperplasia of rats,obviously decreased the ear edema of the mice,obviously reduced the foot swelling. Conclusion： Linderae Radix has certain analgesic and anti-inflammatory effects,suggesting they may be worth further investigation.
出处
《中华中医药学刊》
CAS
北大核心
2015年第4期910-912,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省中医药管理局项目(2011ZB063)
关键词
乌药
生物碱
镇痛作用
抗炎作用
Linderae Radix
alkaloids
analgesic effect
anti-inflammatory effect
