摘要
通过对氨基酸席夫碱合成方法的改进,合成了未见报导的4-OH-Sal-L-Met。K席夫碱及其锰(Ⅱ)配合物,并由元素分析、热重——差热分析、摩尔电导、红外光谱、氢核磁共振谱、电子光谱进行了表征。抗癌活性初步试验表明:锰(Ⅱ)配合物对艾氏腹水癌具有显著的抗癌活性,其抑制率达64.71%。
The new Schiff base of 4-OH-Sal-L-Met. K and its Mn(Ⅱ) complex have been synthesized by an improved synthetic method. Both of them were characterized by elemental analysis, thermoanalysis, conductance measurement, IR, ~1H-NMR and electronic spectra. The preliminary test of anticancer activity in vivo showed that Mn(Ⅱ) complex had effective anticancer activity against Ehrlich ascites carcinoma, the inhibition ratio was as high as 64.71%.
出处
《华中师范大学学报（自然科学版）》
CAS
CSCD
1989年第3期351-356,共6页
Journal of Central China Normal University：Natural Sciences
基金
国家自然科学基金
关键词
席夫碱
L-甲硫氨酸
锰配合物
Schiff base
L-Methionine
Mn(Ⅱ) complex
Anticancer activity
