摘要
含氟肉桂醛与4-氨基-5-(3,4,5-三甲氧基苯基)-1,2,4-三唑-3-硫酮(2)缩合生成5-(3,4,5-三甲氧基苯基)-4-取代苯基烯丙亚胺基-1,2,4-三唑-3-硫酮(3),再烷基化为新型含氟肉桂醛1,2,4-三唑亚胺(4).化合物结构经1HNMR,13CNMR,IR以及元素分析确认,并用X-ray单晶衍射测定了化合物4g的晶体结构,证实了分子中两个环外双键N=C和C=C均为E-式构型.初步生物活性测试结果表明,部分化合物具有抗植物病毒活性.
A series of 4-（substituted-3-phenylallyideneamino）-3-（3,4,5-trimethoxyphenyl）-1H-1,2,4-triazole-5（4H）-thione （3） were synthesized by condensation reaction of 4-amino-3-（3,4,5-trimethoxyphenyl）- 1H-1,2,4-triazole-5（4H）-thione （2） with various fluorocinnamaldehydes. Alkylation of 3 with alkyl halides afforded N-1,2,4-triazole moieties imines containing fluorocinnamylidene 4. Their structures were confirmed by 1H NMR, 13C NMR, IR and elemental analyses. The single crystal structure of compound 4g was deter- mined by X-ray diffraction analysis, which revealed that the two double bonds N=C and C=C outside the rings were of E,E-configurations. The preliminary bioassay showed that some of them exhibited moderate antiviral activity.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2010年第4期569-575,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.20962005
20562003)资助项目
