摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征患者体内炎症因子与嗜睡评分的相关性。方法:选择就诊于解放军第463医院的阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)患者40例作为OSAHS组,另选择同期健康受试者40例作为健康组。以问答形式进行Epworth嗜睡量表(Epworth Sleepiness Scale,ESS)评分。留取晨起空腹血标本,分析两组血清肿瘤坏死因子α(tumor necrosis factor-alpha,TNF-α)、丙二醛(malondialdehyde,MDA)、谷胱甘肽(glutathione,GSH)、超氧化物歧化酶(superoxide dismutase,SOD)水平改变及其与ESS评分的相关性。结果:OSAHS组ESS评分、血清TNF-α、MDA较健康组升高(P<0.05);OSAHS组血清GSH、SOD较健康组降低(P<0.05)。两组受试者ESS评分与血清TNF-α(r=0.815)、MDA(r=0.528)、GSH(r=-0.433)、SOD(r=-0.607)均相关(P<0.01)。结论:OSAHS患者血清TNF-α、MDA、GSH、SOD改变,其变化程度与嗜睡情况相关。
Objective：To analyze the correlation between inflammatory factors and sleepiness A total of scores in patients with obstructive sleep apnea hypopnea syndrome（OSAHS）.Methods：Fourty patients with obstructive sleep apnea hypopnea syndrome treated in the No.463 Hospital of PLA were selected as the OSAHS group.40 healthy subjects were selected as the healthy group.Sleepiness scores were obtained by using the Epworth Sleepiness Scale（ESS）in the form of questions and answers.The morning fasting blood samples were taken,changes in the levels of serum tumor necrosis factoralpha（TNF-α）,serum malondialdehyde（MDA）,serum glutathione（GSH）and serum superoxide dismutase（SOD）and their correlation with sleepiness were analyzed.Results：The ESS score,serum TNF-αand serum MDA of the OSAHS group were higher than those of the healthy group（P〈0.05）.Serum GSH and serum SOD of the OSAHS group were lower than those of the healthy group（P〈0.05）.The ESS scores of both groups were correlated with serum TNF-α（r=0.815）,MDA（r=0.528）,GSH（r=-0.433）and SOD（r=-0.607,P〈0.01）.Conclusions：The serum TNF-α,MDA,GSH,and SOD levels of OSAHS patients change,and they were related to sleepiness.
出处
《中国临床医学》
2017年第2期290-292,共3页
Chinese Journal of Clinical Medicine
基金
全军“十二五”科研课题(CWS11J207)~~
