摘要
目的分析阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者相关炎性因子的表达及与其动脉粥样硬化的相关性。方法对本院呼吸内科收治的65例OSAHS患者根据睡眠呼吸暂停低通气指数(AHI)分为轻度(22例)、中度(23例)和重度(20例)3组,予以持续气道内正压(CPAP)治疗;并选取同时段予以常规体检的健康人群(25例)作为对照组,监测四组人群白细胞介素-18(IL-18)、肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)水平、颈动脉内膜中膜厚度(IMT)以及高密度脂蛋白胆固醇(HDL-ch)、低密度脂蛋白胆固醇(LDL-ch)、甘油三酯表达情况。结果对照组平均血氧饱和度(SaO2)、最低SaO2指数最高,AHI及颈动脉IMT以及IL-18、TNF-α、ET-1、HDL-ch水平最低,四组LDL-ch、甘油三酯水平对比无统计学意义(P>0.05);OSAHS患者中,随病情的加重,其平均SaO2、最低SaO2逐渐降低;AHI、颈动脉IMT及上述炎性因子逐渐升高,组间对比具有统计学意义(P<0.05);治疗后,OSAHS患者最低SaO2均明显上升,AHI及上述炎性因子明显降低(P<0.05);而颈动脉IMT、LDL-ch、HDL-ch以及甘油三酯三组对比无统计学意义(P>0.05);经相关性分析,OSAHS患者上述炎性因子水平与平均SaO2、最低SaO2呈负相关,与AHI和颈动脉IMT呈正相关(P<0.05)。结论 OSAHS患者其颈动脉IMT增厚,其炎性因子水平与病情严重程度呈正相关。
Objective To analyze the expression of related inflammatory factors in patients with obstructive sleep apnea hypopnea syndrome(OSAHS)and the correlation with atherosclerosis.Method 65 patients with OSAHS admitted to our department of respiratory medicine were selected and were divided into the mild group(22 cases),the moderate group(23 cases)and the severe(20 cases)group according to the sleep apnea hypopnea index(AHI).The patients were treated with continuous positive airway pressure(CPAP),and healthy subjects(25 patients)who underwent routine physical examination at the same time were selected as the control group,and interleukin-18(IL-18),tumor necrosis factor-α(TNF-α),endothelin-1(ET-1)levels and carotid intima-media thickness(IMT),high-density lipoprotein cholesterol(HDL-ch),low-density lipoprotein cholesterol(LDL-ch),and triglycerides were monitored in four groups.Results The average oxygen saturation(SaO2)and the lowest SaO2 index were the highest in the control group,and the AHI,carotid IMT and IL-18,TNF-α,and ET-1 were the lowest,and there was no significant difference in LDL-ch and triglyceride levels in the four groups(P>0.05).In patients with OSAHS,the average SaO2 and the lowest SaO2 decreased gradually with the severity of the disease,and AHI,carotid IMT and the above inflammatory factors gradually increased,and the differences in the four groups were statistically significant(P<0.05).After treatment,the lowest SaO2 in patients with OSAHS significantly increased,AHI,carotid IMT and the above inflammatory factors significantly decreased(P<0.05).There was no significant difference between the three groups in the carotid IMT,LDL-ch,HDL-ch,and triglycerides(P>0.05).Correlation analysis showed that the levels of above inflammatory factors in OSAHS patients were negatively correlated with mean SaO2 and lowest SaO2,and positively correlated with AHI and carotid IMT(P<0.05).Conclusion In patients with OSAHS,the carotid IMT is thickened,and the level of inflammatory factors is positively correlated with the severity of the disease.
作者
班健
罗雁
韦圳原
BAN Jian;LUO Yan;WEI Zhenyuan(Department of Respiratory,Qinzhou Hospital of Traditional Chinese Medicine,Qinzhou,Guangxi,China,535099)
出处
《分子诊断与治疗杂志》
2020年第11期1522-1526,共5页
Journal of Molecular Diagnostics and Therapy
基金
广西自然科学基金项目(2015GXNSFBA139132)。
