摘要
目的:考察黄麦合剂中淫羊藿苷、二苯乙烯苷、金丝桃苷的稳定性。方法:以黄芪甲苷、巴戟天药材的TLC鉴别试验,以及淫羊藿苷、二苯乙烯苷、金丝桃苷的HPLC色谱法含量测定为指标,考察黄麦合剂在加速试验及长期试验条件下的稳定性。结果:在加速试验及长期试验条件下,黄芪甲苷、巴戟天药材以及淫羊藿苷具有良好的稳定性;二苯乙烯苷、金丝桃苷在加速试验、长期试验条件下稳定性差。结论:黄麦合剂各成分中二苯乙烯苷、金丝桃苷稳定性不佳,应尝试改造成固体剂型,以保证稳定性。
Objective： To investigate the stability of icariin, 2,3,5,4＇-tetrahydroxy-stilbene-2-O-β-D-glucoside and hyperoside in Huangmai mixture. Methods： TLC was used to identify astrogaloside IV and Morindae officinalis Radix, and HPLC was used to determine the contents of icariin, 2,3,5,4＇ -retrahydroxy-stilbene-2-O-β-D-glucoside and hyperoside. The stability of Huangmai mixture under the conditions of accelerated testing and long-term testing was assessed. Results： Astrogaloside IV, Morindae officinalis Radix and icariin showed good stability during the accelerated testing and long-term testing. The contents of 2,3,5,4＇ -tetrahydroxy-stilbene- 2-O-β-D-glucoside and hyperoside declined quickly during the stability testing. Conclusion： Hyperoside and 2,3,5,4＇ -retrahydroxystilbene-2-O-β-D-glueoside are unstable in Huangrnai mixture. A novel solid dosage form of Huangmai should be developed to obtain better stability.
出处
《中国药师》
CAS
2017年第5期916-920,共5页
China Pharmacist
基金
上海浦东新区科技局中医药技术创新体系项目(编号:PKM2010-13)
上海市科学技术委员会科技支撑项目(编号:12401900502)
关键词
黄麦合剂
黄芪甲苷
巴戟天
淫羊藿苷
二苯乙烯苷
金丝桃苷
加速稳定性
长期稳定性
中药复方
Huangmai mixture
Astrogaloside IV
Morindae officinalis Radix
Icariin
2,3,5,4＇-Tetrahydroxy-stilbene-2-O-β-D- glncoside
Hyperoside
Accelerated testing
Long-term testing
Chinese herbal compound formula
