摘要
目的观察地佐辛联合氟比洛芬酯经静脉自控镇痛用于高龄骨科患者的镇痛效果。方法择期手术ASAⅠ~Ⅱ级患者60例随机分成两组(n=30),A组(对照组):术毕前15 min缓慢静注芬太尼50μg作为负荷剂量,术后持续静脉输注芬太尼16μg/h+昂丹斯琼160μg/h;B组(实验组):术前15 min静注氟比洛芬酯50 mg,术毕前20 min静注地佐辛5 mg作为负荷剂量,术后持续静脉输注地佐辛0.5 mg/h+氟比洛芬酯4 mg/h+昂丹斯琼160μg/h。观察并记录患者术后2、4、6、12、24、48 h视觉模拟评分(VAS)、追加补救镇痛药的例数及不良反应的发生例数。结果术后2、4、6、12、24、48 h,B组镇痛VAS评分低于A组(P<0.05或P<0.01)。在术后2~48 h内A组有9例需静注地佐辛来缓解疼痛,B组仅1例,两组比较有显著性差异(P<0.01)。结论地佐辛联合氟比洛芬酯经静脉自控镇痛用于高龄患者安全、效果确切、并发症少,优于芬太尼经静脉自控镇痛。
Objective To observe the effect of dezocine combined with flurbiprofen on postoperative analgesia in elderly patients with orthopedics surgery. Methods 60 cases of ASA Ⅰ ~ Ⅱ level elective surgery patients were randomly divided into two groups（ n=30）,Group A（ control group） ： 15 min before the end of surgery slow intravenous push Fentanyl injection 50μg as loading dose,postoperative continuous intravenous Fentanyl 16μg/h＋Ondansetron 160μg/h; Group B（ experimental group） ： 15 min before the operation intravenous Flurbiprofen Axetil 50 mg,20 min before the end of surgery with Dezocine 5mg intravenous injection as loading dose,postoperative continuous intravenous influsion to Dezocine 0. 5mg/h ＋ Flurbiprofen Axetil 4mg/h ＋Ondansetron 160μg/h. Observed and recorded the postoperative patients with 2,4,6,12,24,and 48 h visual Analogue Scale（ VAS）,additional remedy analgesic cases and the occurence of adverse reaction cases.Results Postoperation of 2,4,6,12,24 and 48 h,group B analgesia VAS score lower than group A（ P〈0.01 or P〈0.05）.The rate of good analgesia of group A was 70%（ 21/30） compared to group B was 93%（ 28/30） was good,comparison of the two groups had significant difference（ P〈0.05）. Within 2 ~ 48 h after surgery in group A with 9cases need intravenous Dezocine to relieve the pain,only 1 case in group B,comparison of the two groups had significant difference（ P〈0.01）.Conclusions Dezocine combined with flurbiprofen on postoperative analgesia in elderly patients is safe,exact effect,which has better effect and less complication than fentanyl.
出处
《齐齐哈尔医学院学报》
2017年第4期389-391,共3页
Journal of Qiqihar Medical University
