摘要
基质辅助激光解吸电离飞行时间质谱(matrix-assisted laser desorption ionization time-of-flight mass spectrometry,MALDI-TOF-MS)作为一种新的质谱技术成功检测出许多与疾病相关的新型生物标记物,尤其在肿瘤的诊治方面,其可以快速检测出癌症患者体内特异的蛋白表达,辅助制定个体化的治疗方案,预测治疗效果以及复发的可能性。近年来,国内外学者开展了多项MALDI-TOF-MS在卵巢癌差异蛋白检测、化疗耐药相关分子检测方面的研究。综述MALDI-TOF-MS技术的起源与现状,及其对卵巢癌诊断治疗的研究进展,所面临的挑战和应用前景,为卵巢癌的防治、诊断及治疗等提供新的思路和方法。
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry（MALDI-TOF-MS） is a kind of mass spectrometry technology, and it has successfully detected many new biomarkers, which is related to diseases, especially in the aspects of diagnosis and treatment of tumor,moreover it can quickly detect specific proteins expressed in cancer patients, aid to set specific treatments, and predict the outcome of treatment and the possibility of recurrence. In recent years, domestic and foreign scholars have carried out a number of MALDI-TOF-MS study,which is about the analysis of differential promoetic and the detection of molecular protein related to drug resistance in ovarian cancer. The origin and present situation of MALDI-TOFMS technology,the research progress in the diagnosis and treatment of ovarian cancer, the challenges and application prospect,will be discussed in this paper. These will provid new ideas and methods for ovarian cancer prevention, diagnosis and treatment.
出处
《国际妇产科学杂志》
CAS
2017年第2期146-149,共4页
Journal of International Obstetrics and Gynecology
基金
福建省自然科学基金(2014J01278)
福建省卫生厅青年科研课题(2014-ZQN-ZD-5)
关键词
基质辅助激光解吸电离飞行时间质谱
光谱法
质量
基质辅助激光解吸电离
质谱分析法
卵巢肿瘤
生物学标记
Matrix assisted laser dissociation ionization time of flight mass spectrometry
Spectrometry
mass
matrix-assisted laser desorption-ionization
Mass spectrometry
Ovarian neoplasms
Biological markers
