摘要
目的 探讨骨肉瘤肺转移患者的预后及其影响因素。方法 回顾性分析2007年4月至2015年9月间收治的104例骨肉瘤肺转移患者的临床资料，采用Kaplan-Meier法和Log rank检验进行单因素生存分析，采用Cox回归模型进行多因素生存分析。结果 104例骨肉瘤肺转移患者的1、2、5年生存率分别为93.3%、61.5%和11.5%；中位生存时间为33个月。单因素分析显示，性别、年龄、肺转移时间和其他部位转移情况与患者的预后均无关（均P〉0.05）；肺转移灶数目、原发肿瘤化疗效果和肺转移灶治疗方式与患者的预后均有关（均P〈0.05）。多因素分析显示，肺转移灶数目、原发肿瘤化疗效果和肺转移治疗方式均为影响患者预后的独立因素（均P〈0.05）。结论 对于较晚发生肺转移且行积极治疗的骨肉瘤患者的预后较好。采用手术切除和辅助化疗等治疗手段，能有效地延长骨肉瘤肺转移患者的生存时间。
Objective To investigate the prognosis of osteosarcoma patients with lung metastases and its correlated factors.Methods The clinical data of 104 osteosarcoma patients with lung metastasis from April 2007 to September 2015 were retrospectively analyzed. Univariate analysis was performed using Kaplan-Meier and Log rank test. Multivariate Cox regression was applied to analyze independent prognostic factor for patient survival.Results The one-year, two-year and five-year survival rates of the 104 osteosarcoma patients with lung pulmonary metastasis were 93.3%, 61.5% and 11.5%, respectively, and the median survival time was 33 months. The univariate analysis revealed that number of lung metastases, objective response of first-line chemotherapy and therapeutic methods for lung metastases were significant prognostic factors for patient survival, whereas gender, age, time to lung metastasis and time to other metastasis were not （P〉0.05）. The multivariate analysis indicated that number of lung metastases, objective response of first-line chemotherapy and therapeutic methods for lung metastases were independent significant prognostic factors for patient survival.Conclusions The prognosis of osteosarcoma patients with advanced lung metastases and active treatment is better. Surgery and adjuvant chemotherapy could effectively prolong survival time for osteosarcoma patients with pulmonary metastasis.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2017年第4期263-268,共6页
Chinese Journal of Oncology
基金
浙江省中医药科技计划（2015ZB81）
关键词
骨肉瘤
肿瘤转移
肺肿瘤
预后
Osteosarcoma
Neoplasm metastasis
Lung neoplasms
Prognosis
