摘要
作为与胆胰系统疾病相关性较高的肿瘤标志物,糖类抗原199(CA199)在良恶性梗阻性黄疸的鉴别中具有重要作用。近年来,由于受到炎症、Lewis血型、总胆红素等限制因素的影响,CA199的假阳性率与假阴性率明显上升,其鉴别良恶性梗阻性黄疸的价值受到了影响。然而,通过转变策略(如动态监测血清CA199治疗前后变化)以及通过多种指标联合(如总胆红素、C反应蛋白、多种肿瘤标志物、微RNA、影像学检查)的方式,可使CA199鉴别良恶性梗阻性黄疸的价值明显提高。
As a tumor marker of higher correlation in biliary-pancreatic diseases,carbohydrate antigen（CA） 199 plays an important role in differentiating benign or malignant obstructive jaundice. CA199 is reported to be influenced by inflammation,total bilirubin and Lewis blood group in recent years,which could reduce its value in differentiating benign or malignant obstructive jaundice with higher rate of false positives and false negative rate. However,researches show that we could change strategies including monitoring preoperative or postoperative CA199 levels and combining CA199 with multiple factors（e. g,total bilirubin,C-reactive protein,a variety of tumor markers,microRNA and imaging examination） to improve its differential diagnosis value.
出处
《医学综述》
2017年第6期1080-1084,共5页
Medical Recapitulate
