摘要
目的评价清开灵注射液单用及其联合硫酸阿米卡星注射液、注射用头孢哌酮舒巴坦钠、注射用亚胺培南西司他丁钠、注射用替加环素对鲍曼不动杆菌的体外抑菌作用。方法用微量肉汤稀释法,分别测定清开灵注射液、硫酸阿米卡星注射液、注射用头孢哌酮舒巴坦钠、注射用亚胺培南西司他丁钠、注射用替加环素对30株鲍曼不动杆菌的最低抑菌浓度(MIC);同时测定清开灵注射液与硫酸阿米卡星注射液、注射用头孢哌酮舒巴坦钠、注射用亚胺培南西司他丁钠、注射用替加环素联合用药后对该菌株的MIC,计算分级抑菌浓度(FIC)。结果鲍曼不动杆菌对硫酸阿米卡星注射液、注射用头孢哌酮舒巴坦钠、注射用亚胺培南西司他丁钠、注射用替加环素的MIC分别为12 500μg/ml、31.25μg/ml、0.5μg/ml,0.5μg/ml,对清开灵注射液的MIC为注射液稀释到原浓度的1/32,清开灵注射液联合硫酸阿米卡星注射液、注射用头孢哌酮舒巴坦钠、注射用亚胺培南西司他丁钠、注射用替加环素的FIC范围为0.31~0.56。结论清开灵注射液单药对鲍曼不动杆菌有一定的体外抑菌作用,与抗菌药物联合用药时可产生较好的相加或协同作用,并且能够减少常规抗菌药物的用量。
Objective To evaluate the effects on in vitro anti-acinetobacterbaumannii with simple use of qingkailing injection and the combined medication with amikacin sulfate injection,injectable cefoperazone sodium and sulbactam sodium,injectable imipenemcilastatin sodium and injectable tigecycline. Methods The micro-broth dilution method was used to determine MIC of 30 ancinetobacterbaumannii withqingkailing injection,amikacin sulfate injection,injectable cefoperazone sodium and sulbactam sodium,injectable imipenemcilastatin sodium and injectable tigecycline separately as well as MIC with the combined medication of qingkailing injection and amikacin sulfate injection,injectable cefoperazone sodium and sulbactam sodium,injectable imipenemcilastatin sodium and injectable tigecycline. The fractional inhibitory concentration（FIC）was calculated. Results MIC to ancinetobacterbaumanniiwas 12 500 μg/ml,31. 25 μg/ml,0. 5 μg/ml and0. 5 μg/ml with amikacin sulfate injection,injectable cefoperazone sodium and sulbactam sodium,injectable imipenemcilastatin sodium and injectable tigecyclineseparately. MIC of qingkailing injection was 1/32 of the primary concentration. FIC was ranged from 0. 31 to 0. 56 with the combined medication. Conclusion The simple use of qingkailinginjection has a certain of in vitro antibacterial effect on ancinetobacterbaumannii. The combined medication doubles or collaborates the effects and reduces the common dose of general antibaterial drugs.
作者
马维娜
孟拥军
MA Wei-na MENG Yong-jun(Department of Pharmacy, Shanghai Jiading District Center Hospital, Shanghai 201800)
出处
《世界中西医结合杂志》
2017年第2期192-195,共4页
World Journal of Integrated Traditional and Western Medicine
基金
上海市嘉定区科委医学科研课题计划(2014-KW-08)
关键词
清开灵注射液
鲍曼不动杆菌
体外抑菌作用
微量肉汤稀释法
Qingkailing Injection
Acinetobacterbaumannii
In Vitro Antibacteria
Micro-Broth Dilution Method
