摘要
目的:测定盐酸苯环壬酯油水分配系数,研究不同pH值对药物脂水分配系数的影响,为盐酸苯环壬酯新剂型的处方设计提供理论参考。方法:本实验采用摇瓶-高效液相色谱法测定盐酸苯环壬酯在不同pH值条件下正辛醇-水/缓冲液体系中的表观脂水分配系数。结果:盐酸苯环壬酯的脂水分配系数lgP值为1.29±0.16;在pH为1.2,3.0,4.5,5.0,5.5,6.0,6.8,7.0,8.0,9.0的环境中,脂水分配系数lgP值分别为0.31,0.72,1.16,1.34,1.99,2.26,2.22,1.61,2.34,3.24。结论:盐酸苯环壬酯的脂水分配系数与介质的pH值有关,在pH4.5~8.0生理条件下,盐酸苯环壬酯的脂溶性较好,水溶性差。
OBJECTIVE To determine the apparent oil/water partition coefficients of phencynonate hydrochloride in n-octanol-water/buffer solution system and study its effect of pH value,and privide a reference for new dosage forms of benzene ring nonyl ester hydrochloride.METHODS The apparent oil-water partition coefficient of phencynonate hydrochloride was measured by shake-flask method and determined by HPLC.The effects of different pH values on apparent octanol-water partition coefficient of phencynonate hydrochloride were determined.RESULTS The apparent oil-water partition coefficient of phencynonate hydrochloride was 1.29±0.16.When the pH values of the solution were 1.2,3.0,4.5,5.0,5.5,6.0,6.8,7.0,8.0,9.0,the corresponding average lgP values of the partition coefficient of phencynonate hydrochloride were 0.31,0.72,1.16,1.34,1.99,2.26,2.22,1.61,2.34 and 3.24,respectively.CONCLUSION The apparent oil/water partition coeficients of phencynonate hydrochloride is correlated to pH value of the medium.The drug is more soluble in oil than in water at physiological pH values.
出处
《中国医院药学杂志》
CAS
北大核心
2017年第5期409-412,共4页
Chinese Journal of Hospital Pharmacy
基金
国家"十二五"重大新药创制科技重大专项经费资助课题(编号:2013ZX09J13109-05C)
