摘要
目的为观察军事医学科学院研制的抗运动病（Ｍｏｔｉｏｎｓｉｃｋｎｅｓｓ，ＭＳ）新药盐酸苯环壬酯（Ｐｈｅｎｃｙｎｏｎａｔｅｈｙｄｒｏｃｈｌｏｒｉｄｅ，ＰＣＨ）的疗效。方法选科里奥利旋转刺激耐受水平低于９０°／ｓ的受试者９人，进行下列试验：①ＰＣＨ对急性ＭＳ的预防作用：观察受试者在电动转椅旋转过程中的胃电周期和急性ＭＳ症状；②ＰＣＨ对视前庭相互作用的影响：观察视动性眼震（Ｏｐｔｏｋｉｎｅｔｉｃｎｙｓｔａｇｍｕｓ，ＯＫＮ）、前庭眼动反身（Ｖｅｓｔｉｂｕｌａｒｏｃｕｌａｒｒｅｆｌｅｘ，ＶＯＲ）和视前庭眼动反射（Ｖｉｓｕａｌ－ｖｅｓｔｉｂｕｌａｒｏｃｕｌａｒｒｅｆｌｅｘ，ＶＶＯＲ）的频率和最大慢相速度。用东莨菪碱和安慰剂作对照，将ＰＣＨ分为每次服２ｍｇ和４ｍｇ两组，严格按双盲法给药。用前庭功能检查仪评定结果。结果ＰＣＨ有显著的预防ＭＳ的效应，对ＯＫＮ、ＶＯＲ和ＶＶＯＲ三种眼动反射均有一定的抑制作用，且其效应有剂量依赖性。结论ＰＣＨ具有与东莨菪碱相近的抗运动病效应。
Objective To investigate the antimotion sickness effect of phencynonate hydrochloride(PCH) developed by the Military Medical Academy. Methods Nine young men with Coriolis rotating stimulation tolerance level below 90°/s were chosen to undergo 2 experiments.PCH(2 mg or 4 mg),scoplamine(0.3 mg or 0.6 mg),and placebo were assigned to subjects in double blind and random fashion.①In order to explore the antimotion sickness effect of PCH, electrogastrogram were recorded before,during,and after rotation stimulation and motion sickness( MS) symptoms were recorded immediately after rotation. ②In order to explore the influence of PCH on visual vestibular interaction,frequency and maximal slow phase velocities of optokinetic nystagmus(OKN),vestibular ocular reflex(VOR) and visual vestibular ocular reflex(VVOR) were measured after taking assigned drugs. Results PCH has significant antimotion sickness effect,and inhibitory effects on OKN,VOR and VVOR.These effects were dose dependant. Conclusion The antimotion sickness effect of PCH is similar to that of scoplamine.
出处
《中华航空航天医学杂志》
CSCD
1997年第1期10-14,共5页
Chinese Journal of Aerospace Medicine
关键词
盐酸苯环壬酯
运动病
视前庭相互作用
药物疗法
Phencynonate hydrochloride Motion sickness Visual vestibular interaction
