摘要
目的探讨神经元特异性烯纯化酶(NSE)、癌胚抗原(CEA)及细胞角蛋白19片段(CYFRA21-1)在老年非小细胞肺癌患者中的水平及其对手术预后判断的临床价值。方法选取2013年1月至2015年6月收治的行手术治疗的老年非小细胞肺癌患者73例作为病例组,选取同期收治的60例肺部良性疾病患者作为良性疾病组,健康体检者60例作为对照组,比较3组患者的血清CEA、NSE及CYFRA21-1水平;并比较病例组手术前后、不同临床疗效、有无复发转移患者血清CEA、NSE及CYFRA21-1水平。结果病例组血清CEA、NSE及CYFRA21-1水平明显高于良性疾病组和对照组(P<0.05);术后4周,病例组患者血清CEA、NSE及CYFRA21-1水平均明显低于术前(P<0.05);显效组血清CEA、NSE及CYFRA21-1水平明显高于有效组和无效组(P<0.05),有效组血清CEA、NSE及CYFRA21-1水平明显高于无效组(P<0.05);复发转移患者的血清CEA、NSE及CYFRA21-1水平均明显高于无复发转移患者(P<0.05)。结论老年非小细胞肺癌患者血清CEA、NSE及CYFRA21-1水平明显升高,术后则水平显著降低,且与患者的临床疗效及复发转移有密切关系,对患者手术效果及预后判断有重要临床价值。
Objective To investigate the clinical value of changes of levels of neuron -specific enolase （NSE）, carcino embryonic antigen （CEA）, cytokeratin （CYFRA21-1） in postoperative prognosis evaluation in elderly patients with non small cell lung cancer .Methods Seventy -three elderly patients with non-small cell lung cancer who were admitted and treated in our hospital from January 2013 to June 2015 were selected as case group,and the other 60 patients with benign lung diseases who were admitted and treated in the same period were selected as benign disease group ,moreover 60 healthy subjects were served as control group.The serum levels of CEA,NSE and CYFRA21-1 were detected and compared among the three groups.Besides the serum levels of CEA ,NSE and CYFRA21-1 before and after surgery,in the different clinical efficacy,in the patients with or without recurrence and metastasis were observed and compared in case group .Results The levels of CEA,NSE and CYFRA21-1 in case group were significantly higher than those in benign disease group and control group （ P 〈0.05）.On 4 weeks after operation, the levels of CEA, NSE and CYFRA21-1 were significantly lower than those before operation in case group （ P 〈0.05）.The serum levels of CEA,NSE and CYFRA21-1 in excellently effective group were significantly higher than those in effective group and inefficiency group （ P 〈0.05）, moreover, which in in effective group were significantly higher than those in inefficiency group （ P 〈0.05）.Moreover the serum levels of CEA ,NSE and CYFRA21-1 in patients with recurrence and metastasis were significantly higher than those of patients without recurrence and metastasis （P 〈0.05）.Conclusion The serum levels of CEA,NSE and CYFRA21-1in elderly patients with non small cell lung cancer are increased, however,which are decreased after surgery,moreover,which are closely correlated to the therapeutic effects , recurrence and metastasis of patients,therefor ,which are of important clinical value in evaluating surgical effectiveness and prognosis of patients.
出处
《河北医药》
CAS
2017年第5期675-677,682,共4页
Hebei Medical Journal
