摘要
参考文献方法合成了沙格列汀及其3种差向异构体,通过红外光谱(FT-IR)和多种1D和2D NMR实验确认了它们的化学结构,包括1 H,13 C,DEPT90,DEPT135,1 H-1 HCOSY,HSQC和HMBC实验等.进行了沙格列汀及3种差向异构体的2D NOESY实验,得到其分子内NOE数据,研究这些NOE实验结果,分别证实了它们的立体构型.培养了沙格列汀的晶体,其单晶X射线衍射实验结果与核磁共振实验结果相符合,沙格列汀晶体构型、溶液构型(NMR实验结果)和沙格列汀结合受体蛋白的构型是一致的.
Saxagliptin and it＇s three epimerides were synthesized according to the reported literatures. The chemical structures of these compounds were confirmed through FT-IR,1D and 2D NMR spectroscopies. These experiments included 1H ,13C,DEPT90 ,DEPT135,1 H-1 H COSY, HSQC and HMBC etc. Their configurations were verified using NOE results obtained NMR NOESY experiments. The crystal structure of saxagliptin from X-ray diffraction experiment matched well with the configuration from NMR experiments. The configurations of saxagliptin of crystal form,in solution and after binding to its protein acceptor were same.
作者
孙艳美
张勇
曹文婷
王秋艳
原现瑞
SUN Yanmei ZHANG Yong CAO Wenting WANG Qiuyan YUAN Xianrui(School of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Hebei Shijiazhuang 050018,China Analysis and Testing Center,Hebei University of Science and Technology,Hebei Shijiazhuang 050018,China)
出处
《河北师范大学学报（自然科学版）》
CAS
2017年第1期50-57,共8页
Journal of Hebei Normal University：Natural Science
基金
河北省引进留学人员资助项目(C2013003018)
