摘要
目的研究松花粉对大鼠急性酒精性胃黏膜损伤的影响。方法采用急性酒精性胃黏膜损伤模型,将50只SD大鼠分为正常组、模型组、低、中、高剂量组,给药30 d后,进行胃黏膜病变、组织病理学及生化指标检查。结果与模型组相比,松花粉低、中剂量组肉眼病变损伤积分指数有所降低。高剂量组肉眼病变减轻,损伤积分指数显著降低。此外,高剂量松花粉能显著升高乙醇引起的胃组织匀浆SOD以及NO含量,并阻遏乙醇引起的胃黏膜MDA水平升高。结论松花粉对急性酒精性胃黏膜有较好的保护作用。
Objective To investigate the effects of pine pollen on alcohol induced acute gastric mucosal injury in rats. Methods After alcoholic acute gastric mucosal injury was induced in rats, 50 SD rats were divided into normal group, model group, low, middle and high dose groups. After 30 days, gastric mucosal lesion evaluation, histopathological observation and biochemical index examination were carried out. Results Compared with model group, the damage score indices of gross lesions of the low and middle dose groups decreased to some extent. In high dose group, the damage score index of gross lesion decreased significantly. In addition, the high dose pine pollen treatment increased SOD activity and NO content of stomach tissue significantly, and inhibited the increase of MDA level induced by ethanol. Conclusion The nine nollen has a good nrotective effect on acute gastric mucosal iniurv induced by alcohol.
出处
《食品与药品》
CAS
2017年第1期22-25,共4页
Food and Drug
关键词
松花粉
胃黏膜损伤
大鼠
pine pollen
gastric mucosal injury
rat
