摘要
许多疾病的病理微环境的活性氧自由基(ROS)水平较高,如肿瘤、糖尿病、心血管疾病和神经退行性疾病。随着纳米载体的研究深入,利用疾病微环境中高水平的ROS,研究者探索出许多ROS响应给药系统。ROS响应给药系统在到达病变部位后,对病变组织高水平ROS产生响应,触发药物释放。本文综述了含硫多聚物、含硒多聚物、含碲多聚物、草酸酯多聚物、苯硼酸酯多聚物和不饱和脂质等构成的ROS响应给药系统。该系统还可包载光敏剂,用特定波长的光照射后,产生单线态氧(~1O_2),提高组织内~1O_2浓度,~1O_2使ROS响应给药系统氧化裂解,从而促进药物释放。
Excessive reactive oxygen species（ROS） is associated with an array of pathological conditions,including cancer,diabetes,cardiovascular diseases,and neurodegenerative diseases. However,ROS-responsive materials have drawn attention in the development of drug delivery systems. There are many types of ROS-responsive materials explored in drug delivery applications,including sulfur-based responsive polymers,selenium-based responsive polymers,tellurium-based responsive polymers,oxalate ester-containing polymers,phenylboronic ester-containing polymers and unsaturated lipids. When integrated with ROS-responsive drug delivery systems,a photosensitizer is used as a light-sensitive element to generate ROS,mainly singlet oxygen（~1O_2）,which in turn activates the ROS-triggered drug delivery.
出处
《药学学报》
CAS
CSCD
北大核心
2017年第2期206-213,共8页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(30801441)
军队后勤科研项目(AWS14J011)
关键词
活性氧自由基
给药系统
光敏剂
单线态氧
reactive oxygen species
drug delivery system
photosensitizer
singlet oxygen
