摘要
利用血栓弹力图（TEG）检测老年冠心病患者经皮冠状动脉介入术（PCI）治疗后服用常规双联抗血小板方案后氯吡格雷抵抗发生率及其影响因素。收集2013年1月~2015年12月在某部队医院入院的符合入选条件患者322例,收集患者的各临床指标,根据其二磷酸腺苷（ADP）抑制率结果分组,并对两组患者进行单因素及多因素Logistic回归分析。结果322例老年冠心病PCI术后患者氯吡格雷抵抗发生率为38.2%,氯吡格雷抵抗组ADP抑制率平均为（17.92±9.28）%。将氯吡格雷抵抗的单因素分析中有意义的因素代入多因素Logistic回归分析结果得出,胆固醇、糖化血红蛋白有统计学意义（P〈0.05）。高胆固醇、高糖化血红蛋白是老年冠心病患者PCI术后氯吡格雷抵抗的独立危险因素。
To sum up the clinical and laboratory index of elderly patients with coronary heart disease（CHD）after percutaneous coronary intervention（PCI）,who have clopidogrel resistance after taking conventional dual antiplatelet by thrombelastogram（TEG）,then analyze the incidence and influencing factors about clopidogrel resistance.A total of 322 cases of eligible elderly patients were enrolled from the year of 2013 to 2015,concluded their clinical information,divided into two groups based on ADP inhibition rate,then compare the data between the two groups.The incidence of clopidogrel resistance in 322 cases of elderly patients with coronary heart disease after PCI was 38.2%.The average ADP inhibition rate in clopidogrel-resistance group was（17.92±9.28）%.Logistic regression analysis results indicated that the significant factor for clopidogrel resistance are glycosylated hemoglobin and cholesterol（P 0.05）.High cholesterol and high glycolated hemoglobin may be the independent risk factors for clopidogrel resistance in elderly patients with coronary heart disease after percutaneous coronary intervention.
作者
吴琼
张寒珏
侯素云
程芮
WU Qiong ZHANG Han-jue HOU Su-yun et al(The Armed Police General Hospital, Jinzhou Medical University, Jinzhou 121000, China)
出处
《医学与哲学（B）》
2016年第12期34-36,52,共4页
Medicine & Philosophy(B)
关键词
老年患者
氯吡格雷抵抗
经皮冠状动脉介入术
elderly patients
clopidogrel resistance
percutaneous coronary intervention
