摘要
目的探讨Ki67指数在乳腺癌患者中的临床意义,为乳腺癌的诊治以及预后评估提供参考。方法选取2010年1月至2015年12月本院乳腺科收治的460例乳腺癌患者进行回顾性分析,采用免疫组化法检测Ki67,分析其与乳腺癌其他临床指标间的关系。结果 Ki67指数与年龄、肿瘤T分期、腋窝淋巴结转移状态、组织学分级、ER状态、PR状态和HER-2状态均存着明显相关性(P<0.05),其中Ki67指数与年龄、ER和PR状态呈负相关,而与组织学分级和HER-2状态呈正相关;Luminal B型、HER-2过表达型和三阴性乳腺癌患者的Ki67指数均高于Luminal A型,差异具有显著性(P<0.05)。结论乳腺癌患者Ki67指数对于评估乳腺癌预后具有重要的临床意义。
Objective To investigate the clinical significance of Ki67 index in breast cancer patients, and provide reference for diagnosis and prognosis of breast cancer. Method January 2010 to December 2015 460 cases of breast cancer patients treated in our hospital oncology retrospective analysis, testing Ki67 immunohistochemical method to analyze the relationship between breast cancer and other clinical indicators and analysis. Result Ki67 index and age, tumor T stage, axillary lymph node status, histological grade, ER status, PR status and HER-2 status was kept a significant correlation（P〈0.05）, which Ki67 index and age, ER and PR status was negatively correlated with the histological grade and HER-2 status was positively correlated; Luminal B type,HER-2 overexpression and triple-negative breast cancer patients with Ki67 index were higher than Luminal a type, a significant difference was statistically significant（P〈0.05）. Conclusion Ki67 index in breast cancer patients has important clinical significance to assess the prognosis of breast cancer.
作者
夏银娣
朱慧庭
王庆萍
蒋蓓琦
贺其志
XIA Yin-di ZHU Hui-ting WANG Qing-ping JIANG Bei-qi HE Qi-zhi(Department of Pathology, Shanghai First Maternity and Infant Hospital Tongji University, Shanghai 200040, China Department of Breast, Shanghai First Maternity and Infant Hospital Tongji University, Shanghai 200040, China)
出处
《中国医刊》
CAS
2017年第1期68-71,共4页
Chinese Journal of Medicine
关键词
乳腺癌
预后
基因表达
KI67
Breast cancer
Prognosis
Gene expression
Ki67
