摘要
目的探讨人工流产与中国女性乳腺癌发病风险的关系，为我国人群慎重选择人工流产术及乳腺癌的预防提供科学可信的依据。方法通过检索中国知网学术期刊全文数据库、万方数据库、维普数据库和文献追溯等方法，收集国内公开发表的关于人工流产与中国女性乳腺癌相关的病例对照研究文献。采用Meta（荟萃）分析方法计算人工流产与中国女性乳腺癌的合并效应值OR及其95％的可信区间（95％cI）。结果共检索到257篇文献，依照纳入标准和剔除标准，最终19篇相关文献被纳入。根据异质性分析结果（P〈0．001，，=86％），选择随机效应模型。Meta分析结果显示，人工流产与中国女性乳腺癌的合并效应值OR=1．59，95％CI：1．30-1．94，P〈0．001。根据人工流产的次数进行亚组分析，与无人工流产史相比，人工流产1次、≥2次的合并效应值OR及95％c1分别为1．01（0．93-1．10）和1．69（1．25-2．29）。结论人工流产是中国女性乳腺癌的危险因素，多次人工流产术可增加罹患乳腺癌的风险。
Objective To evaluate the relationship between the risk of breast cancer and induced abortions in China. Methods The literatures from 1998 to 2012 about the correlation between the breast cancer and induced abortions among Chinese female were re- trieved. By estimating those literatures and using Meta -analysis method,we calculated the pooled OR and 95% CI as the assessment of the link between induced abortions and breast cancer. Results According to the results of heterogeneity test（ 12 = 87% ,P 〈 0. 001 ） ,we used the random effect model to summarize the data. The pooled OR（95% CI） was 1.59 （ 1.3 - 1.94）. Subgroup analysis revealed that the pooled OR （95% C1） was 1.01 （0.93 - 1.10） for induced abortion one time, and 1.69（ 1.25 N2.29） for induced abortion more than two times respectively. Conclusion There is a correlation between breast cancer and induced abortions among Chinese women. Repeated induced abortions can increase the risk of breast cancer.
出处
《医学研究杂志》
2014年第2期120-123,共4页
Journal of Medical Research
关键词
乳腺癌
人工流产
危险因素
荟萃分析
Breast cancer
Induced abortion
Risk factor
Meta- analysis
