摘要
目的探讨血清同型半胱氨酸（Hcy）在高血压患者病情程度及诊断的作用。方法采用随机取样法。选取2014年3月至2015年12月到我院就诊的85例高血压患者作为观察组，并对所有患者进行具体详细的检查，根据患者血压水平分为1级高血压组、2级高血压组、3级高血压组；然后选取同一时间段内，无心肾功能异常、无高血压和其他心血管疾病病史的健康志愿者65例作为对照组；然后对各组患者血清中同型半胱氨酸（Hcy）进行检测，将最后所得检测结果进行对比分析。结果观察组患者的平均血清Hcy的水平明显高于对照组患者，两组数据具有明显的差异，所得结果对比具有统计学意义（P〈0．05）。观察组中1级高血压组患者的平均血清Hcy的水平明显低于2级高血压组，数据具有明显的差异，结果具有统计学意义（P〈0．05）；3级高血压组患者的平均血清Hcy的水平明显高于2级高血压组，结果对比具有明显的差异，数据具有统计学意义（P〈0.05）。观察组中高Hcy血症患者所占百分比为82．4％，对照组的高Hcy血症患者所占百分比诶13．8％，观察组明显高于对照组，数据具有明显的差异，所得结果具有统计学意义（P〈0．05）；而观察组中1级高血压组高Hey血症患者所占百分比为50％，2级高血压组为93％，3级高血压组为100％，患者血压越高，高Hcy血症患者所占百分比越大，数据具有明显的差异，结果差异具有统计学意义（P〈0．05）。结论高Hcy血症是原发性高血压发病中的一个危险因素，它能够促进高血压的发生和恶化，患者血压越高，患高Hcy血症的几率越大，且患者平均血清Hcy水平也越高。因此，检测患者血清中Hcy的水平有助于患者病情的诊断和治疗，减少患者发病风险，降低患者病情恶化的几率，在高血压疾病的预防、诊断等方面都具有重要的意义。
Objective Of serum homocysteine （Hey） in severity and diagnosis of hypertension. Methods Random sampling meth od, selected from March 2014 to December2015 to our hospital 85 patients with hypertension as the observation group, and all patients will be specifically detailed examination, based on the severity of the patient＇s condition into level I hypertension group, hypertension group stage 2, stage 3 hypertension group; then select the same period of time, no heart and kidney dysfunction, no history of hyper tension and other cardiovascular diseases, 65 cases of healthy volunteers as a control group; and each group of serum homocysteine （Hey） is detected, the final test results obtained were compared. Results The mean serum Hcy level of the observation group were significantly higher in patients with a significant difference between two sets of data, comparison of the results were statistically significant （P〈0.05）. The mean serum Hey level of the observation group stage 1 hypertension group were significantly lower than grade 2 hypertension group, the data have obvious differences, the results were statistically significant （P^0.05） ; the mean serum level of 3 hypertensive patients Hcy levels were significantly higher than grade 2 hypertension group, the results contrast with a significant difference, the data was statistically significant （P〈0.05）. Observation group of high Hcy in patients with hyperlipidemia percentage was 82.4% in patients with high Hey hyperlipidemia control group, the percentage eh 13.8% in the observation group was significantly higher, the data have obvious differences, the results were statistically significant （P〈0.05） ; while the observation group stage 1 hypertension group, the percentage of patients with high Hey hyperlipidemia was 50%, stage 2 hypertension group was 93%, grade 3 hypertension group was 100%, the higher the blood pressure, high the greater the percentage of patients with Hcy hyperlipidemia, data have obvious differences, the results of a statistically significant difference （P〈0.05）. Conclusion High Hcy hyperlipidemia pathogenesis of hypertension is a risk factor, it can promote the occurrence and aggravation of hypertension, the higher the blood pressure, the greater the chance of suffering from high Hey hyperlipidemia, and patients mean serum Hcy levels more high. Therefore, the detection in serum Hey levels to diagnose and treat the patient＇s condition and reduce the risk of patients and reduce the chance of disease progression in patients, are of great significance in terms of hypertension disease prevention, diagnosis and the like.
出处
《检验医学》
CAS
2016年第B09期7-8,共2页
Laboratory Medicine
