摘要
目的探究原发性高血压患者合并抑郁与血浆同型半胱氨酸水平(Hcy)的相关性。方法选取2011年8月—2012年6月在我院干部病房内科住院治疗的原发性高血压患者163例,通过Zung抑郁自评量表(SDS)和综合医院焦虑抑郁量表抑郁分表筛查患者是否合并抑郁,用循环酶法测定血浆Hcy水平。结果共有69例(42.3%)患者合并抑郁,有31例(19.0%)患者发生高同型半胱氨酸血症(HHcy)。按是否合并抑郁将163例患者分为抑郁组和非抑郁组,两组患者的年龄、体质指数、高血压病程、高血压分级、冠心病合并率间差异均无统计学意义(P>0.05);两组患者的性别构成、Hcy水平及HHcy发生率间差异有统计学意义(P<0.05)。将163例患者按血压水平分为3组,不同血压分级患者血浆Hcy水平间差异无统计学意义(P>0.05),不同血压分级患者SDS评分间差异有统计学意义(P<0.05)。结论原发性高血压患者有较高的抑郁发生率,且存在性别差异,女性高于男性;合并抑郁的原发性高血压患者HHcy发生率及血浆中Hcy水平增加。
Objective To explore the correlation of depression with plasma homocysteine （Hey） in essential hyperten- sion （EH） patients. Methods Depression were screened by Zung self - rating depression scale （SDS） and sublist of hospital anxiety and depression scale （HAD） in 163 EH patients （ 114 males and 52 females） admitted to this hospital from August 2011 to June 2012. Hcy level was determined by enzymatic cycling assay. Results There were totally 69 EH patients combined with depression （42. 3% ）, 31 had hyperhomocysteine （HHcy） in this study. When the patients were divided, according to whether combined with depression, into depressive and non - depressive groups, no significant difference was noted in age, body mass index （BMI）, hypertensive duration, grade of hypertension or combination rate of coronary heart disease （CHD） between 2 groups （P 〉 0.05 ）, there was difference in gender, Hcy level and HHcy incidence （P 〈 0. 05）. When the patients were divid- ed, based on blood pressure （BP） level, into 3 groups, there was no difference in plasma Hcy level between patients with dif- ferent BP degrades （P 〉 0. 05 ）, there was in SDS score （ P 〈 0. 05 ）. Conclusion EH patients have a high incidence of de- pression and there is gender difference （higher in females than in males）. HHcy incidence and plasma Hcy level increase in EH patients combined with depression.
出处
《中国全科医学》
CAS
CSCD
北大核心
2013年第14期1593-1595,共3页
Chinese General Practice
基金
新疆维吾尔自治区自然科学基金项目(2011211A083)
