摘要
同型半胱氨酸是蛋氨酸和半胱氨酸代谢过程中一个重要的中间产物。由同型半胱氨酸的代谢异常导致的高同型半胱氨酸血症已被许多研究证实是心脑血管疾病发病的独立危险因子 ,其致病机理尚不十分明确 ,可能与氧化机制造成的内皮损伤和功能失调 ,破坏体内凝血纤溶平衡 ,刺激血管平滑肌细胞增殖和影响脂质代谢等方面有关。与同型半胱氨酸代谢相关的 5 ,10 -亚甲基四氢叶酸还原酶和胱硫醚 -β-合成酶的基因突变导致酶活性下降 ,食物中 B族维生素 (特别是叶酸 )摄食不足均可影响血浆同型半胱氨酸水平 ,遗传和环境两方面的因素共同决定了血浆同型半胱氨酸水平及其对心脑血管疾病发病的危险性大小。
Homocysteine is an important intermidiate product in the metabolism of methionine and cysteine.Although the results of numerous studies have established that hyperhomocysteinemia caused by abnormal metabolism of homocysteine is an independent risk factor for cardiovascular and cerebrovasscular disease,the pathogenesis remains poorly understood.It may be associated with oxidative mechanisms resulting endothelium injury and dysfunction,disturbance of the balance between coaugulation and fibrinolysis,promotion of vascular smooth cell growth and effect to lipid metabolism.Not only the reduction of enzymatic activity caused by the gene mutation of 5,10 methylenetetrahydrofolate reductase and cystathionine β synthase related to the metabolism of homocysteine,but also inadequate dietary B vitamin content can affect the levels of plasma homocysteine.Both the genetic and environmental factors controbute to the levels of plasma homocysteine and the risk for cardiovascular and cerebrovascular disease.
出处
《心血管病学进展》
CAS
2000年第2期75-78,共4页
Advances in Cardiovascular Diseases
