摘要
目的:通过检测结直肠癌组织中磷酯酰肌醇-3-激酶(PI3K)和埃兹蛋白(Ezrin)表达情况,探讨其表达特点及其临床意义。方法:采用免疫组化光波/微波(lightwave/microwave,LW/MW)-Eli VisionTM法检测100例结直肠癌、30例正常黏膜中PI3 K和Ezrin的表达情况,并分析二者与结直肠癌的关系及意义。结果 :PI3 K和Ezrin蛋白在正常黏膜及结直肠癌中表达阳性率差异均有统计学意义(P<0.05)。而PI3 K蛋白的高表达在结直肠癌TNM分期、浆膜浸润和淋巴结转移中有差异(P<0.05),Ezrin蛋白与结直肠癌浸润深度、淋巴结转移密切相关(P<0.05);二者在结直肠癌组织中的表达无相关性(r=0.06,P>0.05)。结论:PI3K和Ezrin蛋白在结直肠癌的发生发展、侵袭、转移中起着重要作用,能为临床治疗结直肠癌及判断预后提供相关依据。
Objective： To investigate the expression of PI3 K and Ezrin in colorectal adenocarcinoma,and their features and clinical significance. Methods： The expression of PI3 K and Ezrin was detected in 100 cases of colorectal adenocarcinoma and 30 cases of normal mucosa tissue by MW- Eli VisionTMimmunohistochemistry,and analyzed the relation between the expression and colorectal adenocarcinoma. Results： There was statistic signigicance in the expression of PI3 K and Ezrin in normal mucosa and colorectal adenocarcinoma（ P〈0. 05）. The high expression of PI3 K was apparently correlated to TNM stage,serous membrane invasion and lymph node metastasis（ P〈0. 05）. The expression of PI3 K was not related to the expression of Ezrin（ r = 0. 06,P〉0. 05）. Conclusion： PI3 K and Ezrin might play important roles in the development,invasion and metastasis of colorectal adenocarcinoma,which provided important imformation in clinical therapy and predicting prognosis of colorectal adenocarcinoma.
出处
《现代肿瘤医学》
CAS
2017年第4期578-581,共4页
Journal of Modern Oncology
