摘要
[目的]比较长春地辛、顺铂、丝裂霉素合用与长春地辛加顺铂方案对晚期非小细胞肺癌的疗效和毒性。[方法]晚期非小细胞肺癌59例 ,用MVP方案治疗31例 ,用VP方案治疗28例。统计有效率、毒性 ,并以此来判断两组方案的优越性。[结果]有效率MVP组为38.7% ,VP组为35.7 % ,两组比较有效率相近(P<0.05)。毒性反应主要为骨髓抑制 ,且以白细胞和血小板下降明显。MVP组较VP组更为严重(P>0.05)。其次为胃肠道毒性和脱发 ,两组相仿 ,均为1～2级。[结论]MVP方案和VP方案是治疗晚期非小细胞肺癌的有效方案 ,但MVP组的骨髓抑制较VP组更为严重。治疗晚期非小细胞肺癌以VP方案更为理想。
To compare the efficacy and toxicity in MVP and VP regimens for advanced non_small cell lung cancer .Fifty_nine patients with advanced non_small cell lung cancer were divided into two groups including 31 treated with MVP (mitomycin,vindesine and cisplatin) regimen and 28 treated with VP (vindesine and cisplatin)regimen. The reponse rates were 38.7%in group of MVP and 35.7% in group of VP respectively. There was no statistical difference between the two groups (P> 0.05).Main toxicity was myelosuppression including apparent decrease of white blood cell and platelets.Myelosuppression was more severe in group of MVP than that in VP group(P<0.05).Other toxicities including gastrointestinal toxicity and alopecia were similar in two groups.[Conclusions] MVP regimen and VP regimen are both effective in advanced non_small cell lung cancer.However myelosuppression is more severe in group of MVP than that in VP group.VP regimen is more preferable in the treatment of advanced non_small cell lung cancer.
出处
《肿瘤学杂志》
CAS
2002年第4期211-212,共2页
Journal of Chinese Oncology
